Recently I am researching about HYBRID MOLECULES; CYTOTOXICITY; DERIVATIVES; DISCOVERY; CANCER, Saw an article supported by the SERB, DSTDepartment of Science & Technology (India)Science Engineering Research Board (SERB), India [EMR/2016/003706]; DST, Government of IndiaDepartment of Science & Technology (India). Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Panday, AK; Ali, D; Choudhury, LH. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Category: benzodioxans
Herein we report iodine-mediated multicomponent reactions for the synthesis of naphthoquinone-fused pyrroles tethered with a pyrimidine moiety. The reaction of aryl methyl ketones (3) or terminal aryl alkynes (5) in the presence of molecular iodine in DMSO medium followed by sequential addition of barbituric acids (2) and 2-amino-1,4-naphthoquinone (1) provides the corresponding three-component hybrid molecules 4 having naphthoquinone-fused pyrroles tethered with a barbituric acid moiety. This three-component reaction proceeds via metal-free C-H oxidation followed by multi-component cyclization forming three new bonds (2 C-C, 1 C-N) in one pot. Alternatively, the same molecules can also be prepared from the reaction of arylglyoxals, 2-aminonaphthoquinone, and barbituric acids in the presence of a catalytic amount of iodine in methanol medium under reflux conditions. The salient features of these methodologies are: one-pot metal-free method, good yields, wide substrate scope, easy purification of products, and the presence of medicinally important naphthoquinone, pyrrole and pyrimidine moieties in the products.
About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Panday, AK; Ali, D; Choudhury, LH or concate me.. Category: benzodioxans
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem