The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ) is researched.Recommanded Product: 5,5′-Dimethyl-2,2′-bipyridine.Kondori, Tahere; Akbarzadeh-T, Niloufar; Ghaznavi, Habib; Karimi, Zeinab; Shahraki, Jafar; Sheervalilou, Roghayeh; Shahraki, Omolbanin published the article 《A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent》 about this compound( cas:1762-34-1 ) in BioMetals. Keywords: binuclear iron complex dimethyl bipyridine cytotoxic agent; 5,5′-dimethyl-2,2′-bipyridine; Binuclear iron(III) complex; Cytotoxicity; Fish salmon DNA. Let’s learn more about this compound (cas:1762-34-1).
The binuclear iron(III) complex (1), namely, {[Fe(5,5′-dmbpy)2(OH2)]2(O)}(NO3)4 with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex 1 and FS-DNA was investigated by UV-Vis, fluorescence spectroscopy, and gel electrophoresis at physiol. pH (7.2). The DNA binding investigation has shown groove binding interactions with complex 1, therefore the hydrogen binding plays an important role in the interaction of DNA with complex 1. The calculated thermodn. parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander-Waals forces have an important function in Fe(III) complex-DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Mol. docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
In some applications, this compound(1762-34-1)Recommanded Product: 5,5′-Dimethyl-2,2′-bipyridine is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.