I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Design, Synthesis and Anti-Tumor Activity of Novel Benzimidazole-Chalcone Hybrids as Non-Intercalative Topoisomerase II Catalytic Inhibitors published in 2020.0. Recommanded Product: 100-19-6, Reprint Addresses Zhou, W; Du, ZY (corresponding author), Guangdong Univ Technol, Sch Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhibitory effect in the Topo II mediated DNA relaxation assay and anti-proliferative effect in 4 tumor cell lines.4dand4nwere the most potent, with IC(50)values less than 5 mu M, superior to etoposide. Mechanistic studies indicated that the BCHs functioned as non-intercalative Topo II catalytic inhibitors. Moreover,4dand4ndemonstrated versatile properties against tumors, including inhibition on the colony formation and cell migration, and promotion of apoptosis of A549 cells. The structure-activity relationship and molecular docking analysis suggested possible contribution of the chalcone motif to the Topo II inhibitory and anti-proliferative potency. These results indicated that4dand4ncould be promising lead compounds for further anti-tumor drug research.
Welcome to talk about 100-19-6, If you have any questions, you can contact Zhou, W; Zhang, WJ; Peng, Y; Jiang, ZH; Zhang, LY; Du, ZY or send Email.. Recommanded Product: 100-19-6
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem