Recently I am researching about SINGLE-STRANDED-DNA; DAMAGE RESPONSE; BINDING; DISCOVERY; CANCER; DOMAIN; LUNG; CHEMOTHERAPY; INCREASES; REPAIR, Saw an article supported by the NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [R01-CA180710, R41-CA162648]; Tom and Julie Wood Family Foundation. HPLC of Formula: C8H7NO3. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Gavande, NS; VanderVere-Carozza, PS; Pawelczak, KS; Vernon, TL; Jordan, MR; Turchi, JJ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Replication protein A (RPA) is the major human single stranded DNA (ssDNA)-binding protein, playing essential roles in DNA replication, repair, recombination, and DNA-damage response (DDR). Inhibition of RPA-DNA interactions represents a therapeutic strategy for cancer drug discovery and has great potential to provide single agent anticancer activity and to synergize with both common DNA damaging chemotherapeutics and newer targeted anticancer agents. In this letter, a new series of analogues based on our previously reported TDRL-551 (4) compound were designed to improve potency and physicochemical properties. Molecular docking studies guided molecular insights, and further SAR exploration led to the identification of a series of novel compounds with low micromolar RPA inhibitory activity, increased solubility, and excellent cellular up-take. Among a series of analogues, compounds 43, 44, 45, and 46 hold promise for further development of novel anticancer agents.
About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Gavande, NS; VanderVere-Carozza, PS; Pawelczak, KS; Vernon, TL; Jordan, MR; Turchi, JJ or concate me.. HPLC of Formula: C8H7NO3
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem