Recently I am researching about ENDOGENOUS PEROXYNITRITE; RATIOMETRIC DETECTION; NITRIC-OXIDE; LIVING CELLS; PROBE; HEPATOTOXICITY; VISUALIZATION; TOXICITY; STRESS; INJURY, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [21904035, 21877029, 21735001]; National Key R&D Program of China [2019YFA0210103]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2018M642968]. Recommanded Product: 100-19-6. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Cheng, D; Gong, XY; Wu, Q; Yuan, J; Lv, Y; Yuan, L; Zhang, XB. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Peroxynitrite (ONOO-), a highly reactive species, is profoundly involved in many physiological and pathological processes. Change of the ONOO- level usually indicates an abnormal body function. Thus, it is desired to develop a highly reliable ONOO- assay to elucidate its roles in a related disease environment. In this work, we have constructed a ratiometric molecule fluorescent probe RTFP toward ONOO- with high specificity by the combination strategy of probe screening and a rational design method. RTFP displayed excellent detection sensitivity (detection limit: 4.1 nM) and produced a highly ratiometric emission signal (130-fold). Leveraging this probe, we showed the change of ONOO- content in the free-fatty-acid-induced nonalcoholic fatty liver disease (NAFLD) and acetaminophen-induced drug-induced liver injury (DILI) cellular model and for the first time disclosed the involved mechanism of cytochrome P450 2E1 (CYP2E1) enzyme in NAFLD with a DILI pathological environment. Furthermore, RTFP also was utilized to visualize ONOO- fluctuation of living liver tissues in a high-fat-diet-caused NAFLD model. We expected that this probe may help the study of liver injury in the exploration of mechanism and signal path.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem