An article Synthesis of Chalcone-Derived Heteroaromatics with Antibacterial Activities WOS:000587726400012 published article about ADDITION/OXIDATIVE CYCLIZATION; OXIDATION; SOLVENT; ESTERS; FURANS in [Jin, Hui; Jiang, Xia; Wang, Tingshu; Koo, Sangho] East China Univ Sci & Technol, Sch Pharm, Meilong Rd 130, Shanghai 200237, Peoples R China; [Jin, Hui; Jiang, Xia; Yoo, Hyebin; Wang, Tingshu; Koo, Sangho] Myongji Univ, Dept Energy Sci & Technol, Myongji Ro 116, Yongin 17058, Gyeonggi Do, South Korea; [Sung, Chul Gi; Choi, Umji; Lee, Chang-Ro] Myongji Univ, Dept Biol Sci & Bioinformat, Myongji Ro 116, Yongin 17058, Gyeonggi Do, South Korea; [Yu, Haiyang] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 300193, Peoples R China in 2020.0, Cited 31.0. Formula: C8H7NO3. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
An efficient synthetic method of medicinally important chalcone-derived heteroaromatics was proposed, which comprised of conjugate addition of ethyl acetoacetate to chalcones, followed by Mn-III/Co-II-catalyzed oxidative deacetylation. Paal-Knorr reactions of the resulting 1,4-dicarbonyl compounds containing various phenyl substituents produced the corresponding 2-carboethoxy-3,5-diphenyl furans, pyrroles, and thiophenes. The scope, mechanism, and electronic requirements for the phenyl substituents of chalcones in the key radical-medicated deacetylation reaction were fully elucidated. Antibacterial activities of the 21 chalcone-derived heteroaromatics were screened for Escherichia coli, Staphylococcus aureus, and Acinetobacter baumannii. The parent pyrrole 5 a showed most effective inhibition for E. coli and one third of the heteroaromatics exhibited significant inhibition for S. aureus at the concentration of 64 mu g/mL.
Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Jin, H; Jiang, X; Yoo, H; Wang, TS; Sung, CG; Choi, U; Lee, CR; Yu, HY; Koo, S or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem