An article On Water Catalytic Aldol Reaction between Isatins and Acetophenones: Interfacial Hydrogen Bonding and Enamine Mechanism WOS:000473116200008 published article about HENRY NITROALDOL REACTIONS; ORGANIC-SYNTHESIS; ENANTIOSELECTIVE CONSTRUCTION; CONDENSATION; DERIVATIVES; ALDEHYDES in [Han, Jinsong; Zhang, Jin-Lei; Zhang, Wei-Qiang; Gao, Ziwei; Xu, Li-Wen; Jian, Yajun] Shaanxi Normal Univ, Sch Chem & Chem Engn, MOE, Key Lab Appl Surface & Colloid Chem, Xian 710062, Shaanxi, Peoples R China; [Xu, Li-Wen] Hangzhou Normal Univ, Minist Educ, Key Lab Organosilicon Chem & Mat Technol, Hangzhou 310012, Zhejiang, Peoples R China in 2019.0, Cited 38.0. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
On water catalytic aldol reaction catalyzed by polyetheramine (D230) has been developed for easy access to 3-substituted 3-hydroxyindolin-2-ones through the reaction between various substituted isatins and acetophenones/cyclic ketones in high yields under room temperature. Systematic mechanism investigation uncovers the secret for the on water catalytic aldol reaction: comparison of the heterogeneous and homogeneous reaction circumstances with yields of 95 and 20%, respectively, indicates the on-water reaction dominating; interfacial hydrogen bonding between isatin with H2O is tested based on the downfield shift of the C2 and C3’s C-13 NMR signals when water was added to the CDCl3 solution of isatin; Lewis base polyetheramine D230 catalyzes the aldol reaction via the enamine mechanism verified by in situ NMR and ESI-MS analysis.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem