Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1762-34-1, is researched, SMILESS is CC1=CN=C(C=C1)C1=NC=C(C)C=C1, Molecular C12H12N2Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Inorganic Biochemistry called Heteroleptic NiII complexes: Synthesis, structural characterization, computational studies and amoebicidal activity evaluation, Author is Hernandez-Ayala, Luis Felipe; Toledano-Magana, Yanis; Ortiz-Frade, Luis; Flores-Alamo, Marcos; Galindo-Murillo, Rodrigo; Reina, Miguel; Garcia-Ramos, Juan Carlos; Ruiz-Azuara, Lena, the main research direction is nickel bipyridine phen ethanediylbissulfanediylethanediyldipyridine complex preparation redox potential amebicide; antitumor parasiticide nickel bipyridine phen ethanediylbissulfanediylethanediyldipyridine complex; optimized mol structure nickel bipyridine phen ethanediylbissulfanediylethanediyldipyridine complex; crystal structure nickel bipyridine phen ethanediylbissulfanediylethanediyldipyridine complex; Amoebiasis; Amoebicidal activity; DFT calculations; Nickel (II) complexes; pdto ligand.Reference of 5,5′-Dimethyl-2,2′-bipyridine.
In this work, we present the synthesis, characterization, electrochem. studies, DFT calculations, and in vitro amoebicidal effect of seven new heteroleptic NiII coordination compounds The crystal structures of [H2(pdto)](NO3)2 and [Ni(pdto)(NO3)]PF6 are presented, pdto = 2,2′-[1,2-ethanediylbis-(sulfanediyl-2,1-ethanediyl)]dipyridine. The rest of the compounds have general formulas: [Ni(pdto)(N-N)](PF6) where N-N = 2,2′-bipyridine (bpy), 4,4′-dimethyl-2,2′-bipyridine (44dmbpy), 5,5′-dimethyl-2,2′-bipyridine (55dmbpy), 1,10-phenanthroline (phen), 4,7-dimethyl-1,10-phenanthroline (47dmphen) and 5,6-dimethyl-1,10-phenanthroline (56dmphen). The size of N-N ligand and its substituents modulate the compound electronic features and influence their antiproliferative efficiency against Entamoeba histolytica, 56dmphen derivative, shows the biggest molar volume and presents a powerful amoebicidal activity (IC50 = 1.2μM), being seven times more effective than the first-line drug for human amoebiasis metronidazole. Also, increases the reactive oxygen species concentration within the trophozoites. This could be the trigger of the E. histolytica growth inhibition. The antiparasitic effect is described using NiII electron d., molar volume, estimated by DFT, as well as the exptl. redox potential and diffusion coefficients In general, amoebicidal efficiency is directly proportional to the increment of the molar volume and decreases when the redox potential becomes more pos.
Here is a brief introduction to this compound(1762-34-1)Reference of 5,5′-Dimethyl-2,2′-bipyridine, if you want to know about other compounds related to this compound(1762-34-1), you can read my other articles.