Name is 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 4442-54-0, its synthesis route is as follows.,4442-54-0
In a microwave oven vessel the title compound of Preparation 9 (250 mg, 0.86 mmol), 2,3-dihydrobenzo[b][1 ,4]dioxine-6-carboxylic acid (170 mg, 0.94 mmol), HBTU (325 mg, 0.86 mmol) and diisopropylethylamine (0.300 ml, 1.71 mmol) were placed andDMF (3 ml) was added. The mixture was heated at a Biotage Initiator device at 1500C and high absorvance for 15 min. Then HCI 2M was added and the solvent removed in vaccuo. The reaction crude was purified according to purification method A to yield 108 mg (27percent) of the title compound.LRMS: m/z 454 (M+1 )+ Retention time: 19.90min (method C)1H NMR (200 MHz, CDCI3) delta ppm 0.80 (m, J=7.42 Hz, 3 H) 1.28 (m, 2 H) 1.79 (m, 2 H) 2.35 (s, 6 H) 3.77 (s, 3 H) 4.32 (m, 6 H) 6.88 – 7.17 (m, 2 H) 7.23 (s, 2H) 7.66 (s, 1 H).
With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid
Reference£º
Patent; ALMIRALL, S.A.; GRIMA POVEDA, Pedro Manuel; AGUILAR IZQUIERDO, Nuria; MIR CEPEDA, Marta; LOPEZ MARTINEZ, Manuel; WO2010/43377; (2010); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem