Name is 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 4442-54-0, its synthesis route is as follows.,4442-54-0
Preparation of Compound 1, N-(4-methyl-3-nitrophenyl)-2,3-dihydrobenzo[b][1,4]dioxine-6-carboxamide[0001] Oxalyl chloride (1 .40 ml 16.6 mmol) was added dropwise to a solution of 1 ,4- benzodioxane-6-carboxylic acid (2.486 g, 13.80 mmol) and DMF (0.027 ml_, 0.34 mmol) in dry DCM (34 ml_). The reaction mixture was stirred at rt for 3.5 h, and thenconcentrated. The residue was dissolved in DCM and concentrated again. This residue was dissolved in dry DCM (12 mL) and added dropwise to a solution of 4-methyl-3- nitroaniline (2.100 g, 13.80 mmol) and pyridine (2.23 mL, 27.6 mmol) in dry DCM (25 mL). The reaction mixture was stirred at rt for 2 h, and then concentrated. The resulting solid was suspended in MeOH, diluted with water and then isolated by filtration and washed with water to afford the title compound (4.24 g, 98percent) as a pale tan coloured solid. NMR (500 MHz, DMSO) delta 10.39 (s, 1 H), 8.54 (d, J = 2.2 Hz, 1 H), 7.99 (dd, J = 8.4, 2.3 Hz, 1 H), 7.55 (d, J = 2.1 Hz, 1 H), 7.52 (dd, J = 8.4, 2.2 Hz, 1 H), 7.47 (dd, J = 8.4, 0.8 Hz, 1 H), 7.01 (d, J = 8.4 Hz, 1 H), 4.34-4.29 (m, 4H), 2.49 (s, 3H). HRMS (ESI+): calcd for C16H15N2O5 (M + H)+, 315.0976; found 315.0982.
With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydro-1,4-benzodioxine-6-carboxylic acid
Reference£º
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; JONES, Keith; RYE, Carl; CHESSUM, Nicola; CHEESEMAN, Matthew; PASQUA, Adele Elisa; PIKE, Kurt Gordon; FAULDER, Paul Frank; WO2015/49535; (2015); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem