Name is 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde, as a common heterocyclic compound, it belongs to benzodioxans compound, and cas is 29668-44-8, its synthesis route is as follows.,29668-44-8
EXAMPLE 16 Preparation of 1,4-Benzodioxan-6-carboxylic Acid 1,4-Benzodioxan-6-carboxaldehyde (8.87 g, 54 mmoles), 19.68 g methanol, 50.3 wt percent sodium hydroxide (5.99 g) and 30percent aqueous hydrogen peroxide (5.30 g, 46.8 mmoles) were heated in a 250 mL flask for 17 minutes at 39¡ã-52¡ã C. and 18 minutes at 52¡ã-58¡ã C. oil bath temperature. After the moderate foaming had subsided, 30percent aqueous hydrogen peroxide (13.54 g, 119 mmoles) was added in three roughly equal portions over 22 minutes at 58¡ã-66¡ã C. After a twelve minute hold, two additional portions of 30percent hydrogen peroxide (4.24 g and 5.25 g, total now 28.33 g or 250 mmoles) were added 20 minutes apart. Each addition gave moderate transient oxygen evolution. The mixture was heated and stirred for 55 minutes at 67¡ã-47¡ã C. The solution was cooled and 23.62 g of deionized water was added. Neutral oil (2.12 g, predominantly unreacted starting material) was removed by four methylene chloride extractions totaling 10.1 g. Then the extracted aqueous layer was acidified with 37percent aqueous hydrochloric acid and the resulting pasty slurry was shaken well. Filtration with three 20 g water washes and drying gave white crystals of 1,4-benzodioxan-6-carboxylic acid (6.97 g), m.p. 134.2¡ã-136.7¡ã C.
With the complex challenges of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde
Reference£º
Patent; Rohm and Haas Company; US5530028; (1996); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem