Application of 10288-72-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10288-72-9, Name is 6-Hydroxy-1,4-benzodioxane, molecular formula is C8H8O3. In a Article£¬once mentioned of 10288-72-9
Effect of 1,4-dioxanyl substitution on the adrenergic activity of some standard alpha-adrenoreceptor agents
A preliminary communication reported on the pharmacology of the potent partial alpha2-agonist (2-(1,4-benzodioxan-6-ylamino)-2-imidazoline, a 1,4-dioxan derivative of clonidine.Its degree of agonism/antagonism depended upon the peripheral or central alpha2-adrenoreceptor system studied.It was of interest to discover whether a similar substitution of the 1,4-dioxan moiety in other standard alpha-adrenergic agents would similary produce high affinity compounds of complex pharmacological profile.The same substitution when introduced into guanfacine, fenmetazole and tolazoline resulted in unpredictable changes in profile with a reduction in alpha-affinity. – alpha2-adrenoreceptors/antagonism/agonism/clonidine derivatives/1,4-dioxan derivatives
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Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem