Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Ahmed, QU; Zakaria, ZA in [Zaman, Khalid; Rahim, Fazal] Hazara Univ, Dept Chem, Mansehra 21300, Khyber Pakhtunk, Pakistan; [Taha, Muhammad] Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia; [Wadood, Abdul] Abdul Wali Khan Univ Mardan, Dept Biochem, Mardan 23200, Pakistan; [Shah, Syed Adnan Ali] Univ Teknol MARA, Fac Pharm, Cawangan Selangor Kampus, Selangor 42300, DE, Malaysia; [Shah, Syed Adnan Ali] Univ Teknol MARA, Atta Ur Rahman Inst Nat Prod Discovery AuRIns, Cawangan Selangor Kampus PuncakAlam, Selangor 42300, DE, Malaysia; [Ahmed, Qamar Uddin] Int Islamic Univ Malaysia, Kulliyyah Pharm, Dept Pharmaceut Chem, Pahang Dm 25200, Kuantan, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia; [Zakaria, Zainul Amiruddin] Univ Putra Malaysia, Halal Inst Res Inst, Serdang 43400, Selangor, Malaysia published Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study in 2019.0, Cited 48.0. Name: 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threats. In connection with this, we have synthesized twenty derivatives of isoquinoline bearing oxadiazole (1-20), characterized through different spectroscopic techniques such as HREI-MS, H-1-NMR and C-13-NMR and evaluated for thymidine phosphorylase inhibition. All analogues showed outstanding inhibitory potential ranging in between 1.10 +/- 0.05 to 54.60 +/- 1.50 mu M. 7-Deazaxanthine (IC50 = 38.68 +/- 1.12 mu M) was used as a positive control. Through limited structure activity relationships study, it has been observed that the difference in inhibitory activities of screened analogs are mainly affected by different substitutions on phenyl ring. The effective binding interactions of the most active analogs were confirmed through docking study.
Name: 1-(4-Nitrophenyl)ethanone. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem