As a common heterocyclic compound, it belong benzodioxans compound,Methyl 1,4-Benzodioxane-2-carboxylate,3663-79-4,Molecular formula: C10H10O4,mainly used in chemical industry, its synthesis route is as follows.,3663-79-4
General procedure: Methyl 1,4-benzodioxan-2-carboxylate (¡À)-17a was dissolved in ? THF/ ? H2O (1:1 ratio) after which ? lithium hydroxide was added. The reaction was stirred for 3?h until hydrolysis was complete. Next, THF was evaporated and the residue acidified with 10percent HCl. DCM was used for extraction. The organic layers were dried in vacuo to give ? (¡À)-1,4-benzodioxan-2-carboxylic acid 1 in 91percent yield as a white solid; mp 117?119?¡ãC; [lit.23b 125.4]; 1H NMR: delta 4.44 (d, J?=?4.8?Hz, 2H), 4.90 (t, J?=?3.7, 7.6?Hz, 1H), 6.88?6.97 (m, 3H), 6.99?7.02 (m, 1H); 13C NMR: delta 64.63, 71.61, 117.34, 122.38, 141.97, 142.87 173.59; HRMS (ESI) Calcd for C9H8NaO4 (M+Na): 203.0320. Found: 203.0317.
With the synthetic route has been constantly updated, we look forward to future research findings about Methyl 1,4-Benzodioxane-2-carboxylate,belong benzodioxans compound
Reference£º
Article; Rouf, Abdul; Gupta, Pankaj; Aga, Mushtaq A.; Kumar, Brijesh; Chaubey, Asha; Parshad, Rajinder; Taneja, Subhash C.; Tetrahedron Asymmetry; vol. 23; 22-23; (2012); p. 1615 – 1623;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem