Tag: 31127-39-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31127-39-6,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,as a common compound, the synthetic route is as follows.

General procedure: A mixture of 2 (10.0 mmol) in CH2Cl2 was stirred at room temperature, NCS (1.60 g, 12.0 mmol) was then added. The resulted mixture was stirred at reflux and propynol (0.56 g, 10.0 mmol) was added dropwise. After 0.5h, triethylamine (1.01 g, 10 mmol) was added dropwise and refluxed for another 4h. After cooling, the reaction mixture was washed with water and evaporated under reduced pressure. The obtained residue was purified by silica gel chromatography with petroleum ether/ ethyl acetate as eluent to give intermediate 3.

31127-39-6, 31127-39-6 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime 5382382, abenzodioxans compound, is more and more widely used in various.

Reference£º
Article; Pang, Guang Xian; Niu, Chao; Mamat, Nuramina; Aisa, Haji Akber; Bioorganic and Medicinal Chemistry Letters; vol. 27; 12; (2017); p. 2674 – 2677;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO421,mainly used in chemical industry, its synthesis route is as follows.,31127-39-6

General procedure: From exo-glucal 3A. An aqueous solution of NaOCl (5 mL, 9Chl prepared from a 36Chl commercial solution, diluted 4 times) was added slowly with a syringe pump (~16 h) at rt to a solution of methylene exo-glycal 3A (100 mg, 0.29 mmol) and aldoxime (0.58 mmol, 2 eq) in THF (10 mL). The mixture was diluted withwater (10 mL) and extracted with CH2Cl2 (3 20 mL). The organic layer was dried over MgSO4 and concentrated in vacuo. The crude product was purified by silica gel chromatography (petroleum ether/EtOAc, 7:3) to afford the corresponding spiro-isoxazolines 4a,f-j,l-p.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,belong benzodioxans compound

Reference£º
Article; Goyard, David; Konya, Balint; Chajistamatiou, Aikaterini S.; Chrysina, Evangelia D.; Leroy, Jeremy; Balzarin, Sophie; Tournier, Michel; Tousch, Didier; Petit, Pierre; Duret, Cedric; Maurel, Patrick; Somsak, Laszlo; Docsa, Tibor; Gergely, Pal; Praly, Jean-Pierre; Azay-Milhau, Jacqueline; Vidal, Sebastien; European Journal of Medicinal Chemistry; vol. 108; (2016); p. 444 – 454;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO436,mainly used in chemical industry, its synthesis route is as follows.,31127-39-6

General procedure: A mixture of a’ (10.0 mmol) in CH2Cl2 was stirred at room temperature, NCS (1.60 g, 12.0 mmol) was then added. The resulted mixture was stirred at reflux and propynol (0.56 g, 10.0 mmol) was added dropwise. After 0.5 h, triethylamine (1.01 g, 10 mmol) was added dropwise and refluxed for another 4 h. After cooling, the reaction mixture was washed with water and evaporated under reduced pressure. The obtained residue was purified by silica gel chromatography with petroleum ether/ethyl acetate as eluent to give intermediate b’.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,belong benzodioxans compound

Reference£º
Article; Niu, Chao; Yin, Li; Nie, Li Fei; Dou, Jun; Zhao, Jiang Yu; Li, Gen; Aisa, Haji Akber; Bioorganic and Medicinal Chemistry; vol. 24; 21; (2016); p. 5440 – 5448;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,31127-39-6,Molecular formula: C9H9NO3,mainly used in chemical industry, its synthesis route is as follows.,31127-39-6

General procedure: A solution of a respective oxime 2a,b or 5a,b (18 mmol) in acetic anhydride (10 mL) was heated to reflux for 8-12 h. Afterwards, the solvent was then removed in vacuo, the residue was quenched by adding cold water (10 mL), and keeping the temperature of the resulting mixture at 15-20C for 1-2 h. The formed precipitate was isolated, and dried at 40oC to give title compounds 3a,b or 6a,b, respectively.

With the synthetic route has been constantly updated, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,belong benzodioxans compound

Reference£º
Article; Le-Nhat-Thuy, Giang; Dinh, Thuy Van; Pham-The, Hai; Nguyen Quang, Hung; Nguyen Thi, Nga; Dang Thi, Tuyet Anh; Hoang Thi, Phuong; Le Thi, Tu Anh; Nguyen, Ha Thanh; Nguyen Thanh, Phuong; Le Duc, Trung; Nguyen, Tuyen Van; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3741 – 3747;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

31127-39-6, 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

177 mg of the intermediate XXV was dissolved in ethanol, a catalytic amount of palladium hydroxide was added, the air was replaced and hydrogen was introduced, and the reaction was carried out at 30-60 C. for 6 hours. After the reaction was completed, ethanol was distilled off under reduced pressure, and water was added to the residue. Ester extraction, without purification, gives the intermediate 1,4-benzodioxane-7-methylamine directly for the next reaction

As the paragraph descriping shows that 31127-39-6 is playing an increasingly important role.

Reference£º
Patent; East China University of Science and Technology; Chinese Academy Of Sciences Shanghai Pharmaceutical Institute; Li Jian; Lan Lefu; Ni Shuaishuai; Chen Feifei; Wei Hanwen; Li Baoli; Liu Yifu; Mao Fei; Zhu Jin; (157 pag.)CN108117534; (2018); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.31127-39-6,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime,as a common compound, the synthetic route is as follows.

General procedure: A solutionof oxime 1a-k (23 mmol) in isopropyl alcohol (100 mL) was loaded into the autoclave with the fl uoroplastic bush, concentratedHCl (10.5 mL) was added, and a block of the regeneratedcatalyst was fi xed. Hydrogenation was conducted for 3-5 h at20 C and a hydrogen pressure of 10 atm, which was maintainedat this level during the reaction. The reaction course was monitoredby TLC. After the initial oxime disappeared completely,the reaction solution was poured out of the autoclave, the catalystblock was washed with methanol (3¡Á30 mL), and the combinedsolutions were fi ltered from mechanical impurities. The solventwas evaporated, and analytically pure aromatic benzylamines3a-k were obtained.When hydrogenation was conducted in methanol (100 mL),solvent removal was followed by drying residue using azeotropicdistillation with isopropyl alcohol (250 mL). For the hydrogenationof compound 1k, the reaction mixture was additionallypurifi ed by refl ux with active carbon for 1 h. The blockcatalyst was regenerated directly in the reactor at 400 C ina hydrogen fl ow and further used in the next hydrogenationprocedure.

As the paragraph descriping shows that 31127-39-6 is playing an increasingly important role.

Reference£º
Article; Ignatov; Varakutin; Solov?eva; Karmanova; Kozlov; Semenova; Semenov; Russian Chemical Bulletin; vol. 67; 8; (2018); p. 1394 – 1400; Izv. Akad. Nauk, Ser. Khim.; 8; (2018); p. 1394 – 1400,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem