Tag: 20197-75-5

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20197-75-5

To a solution of compound A(0.1 mol) in ethanol (50 mL) was added 85% hydrazine hydrate (1 mL) and the mixture was refluxed for 8-10 h. The reaction mixture was cooled down and the precipitated solid was filtered off and washed with small quantity of ethanol to give intermediate compound B.

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Article; Wang; Liu; Xu; Sun; Russian Journal of General Chemistry; vol. 87; 11; (2017); p. 2671 – 2677; Zh. Obshch. Khim.; vol. 87; 11; (2017); p. 2671 – 2677,7;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.,20197-75-5

Nitric Acid (18 mL) was added dropwise to a solution of 15.0 g (77.3 mmol) of 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester in 45 mL of HOAc. The solution was heated at 60C for 1.5 h. An additional 9 mL of HNO3 was then added and heating was continued for 1.5 h at 70C. The reaction was poured into ice-H2O and the solid product was collected, washed well with H2O and dried. Recrystallization from heptane-toluene yielded 16.8 g of the title compound as yellow crystals: mass spectrum (electron impact, m/e): 239.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,20197-75-5

To compound 2 (0.01 mol) dissolved in dry ethanol (50 mL) 99% hydrazine hydrate (1 mL) was added and the mixture was refluxed for 8-10 h. The reaction mixture was cooled and the solid obtained was filtered, washed with small quantity of ethanol to give 3a.

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Article; Sun, Juan; Cao, Ning; Zhang, Xiao-Min; Yang, Yu-Shun; Zhang, Yan-Bin; Wang, Xiao-Ming; Zhu, Hai-Liang; Bioorganic and Medicinal Chemistry; vol. 19; 16; (2011); p. 4895 – 4902;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

(2) Synthesis of Compound 1 (0146) The compound k (2.01 g), NBS (8.48 g), and carbon tetrachloride (125 ml) were introduced to an eggplant-shaped flask. Then, AIBN (340 mg) was added thereto in a nitrogen atmosphere and heated to reflux for 44 hours. The reaction solution was extracted with chloroform. Subsequently, the extract was washed with saturated saline, dehydrated with sodium sulfate, and concentrated. The concentrate was purified by silica gel column chromatography (Wakosil? C-300) using chloroform alone as an eluent. Thus, the compound 1 was obtained (yield: 2.64 g; yield rate: 73percent).

20197-75-5, As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Patent; RIKEN; Nakano, Takeshi; ASAMI, Tadao; OSADA, Hiroyuki; (31 pag.)US2017/305886; (2017); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.,20197-75-5

Nitric Acid (18 mL) was added dropwise to a solution of 15.0 g (77.3 mmol) of 2,3-dihydro-benzo[1,4]dioxine-6-carboxylic acid methyl ester in 45 mL of HOAc. The solution was heated at 60C for 1.5 h. An additional 9 mL of HNO3 was then added and heating was continued for 1.5 h at 70C. The reaction was poured into ice-H2O and the solid product was collected, washed well with H2O and dried. Recrystallization from heptane-toluene yielded 16.8 g of the title compound as yellow crystals: mass spectrum (electron impact, m/e): 239.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Wyeth Holdings Corporation; EP1117659; (2003); B1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

As a common heterocyclic compound, it belong benzodioxans compound,Methyl 1,4-Benzodioxan-6-carboxylate,20197-75-5,Molecular formula: C10H10O4,mainly used in chemical industry, its synthesis route is as follows.,20197-75-5

General procedure: A mixture of 60% NaH (0.12g, 5mmol) was added in anhydrous THF (10mL), followed by the addition of anhydrous CH3CN (0.21g, 5mmol) and compound 2 (0.42g, 2.5mmol) in the ice bath. Reaction was heated to reflux and stirred for 6h. Upon completion, the reaction mixture was taken up in ice water (30mL) and the pH was adjusted to 5. After filtration, the filtrate was extracted with ethyl acetate (20mL¡Á3). The combined organic phase was washed twice with saturated brine (20mL¡Á2) and dried over anhydrous MgSO4. Then, MgSO4 was filtered out, and the filtrate was concentrated in vacuo, Followed by recrystallization of the residue to afford compound 19a as a pale-yellow solid.

With the synthetic route has been constantly updated, we look forward to future research findings about Methyl 1,4-Benzodioxan-6-carboxylate,belong benzodioxans compound

Reference£º
Article; Heng, Hao; Wang, Zhijie; Li, Hongmei; Huang, Yatian; Lan, Qingyuan; Guo, Xiaoxing; Zhang, Liang; Zhi, Yanle; Cai, Jiongheng; Qin, Tianren; Xiang, Li; Wang, Shuxian; Chen, Yadong; Lu, Tao; Lu, Shuai; European Journal of Medicinal Chemistry; vol. 176; (2019); p. 248 – 267;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

20197-75-5, Methyl 1,4-Benzodioxan-6-carboxylate is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Step B Preparation of 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester To a solution of 5.0 g. of 3,4-ethylenedioxybenzoic acid methyl ester in 5.0 mls. of glacial acetic acid is added dropwise 5.0 mls. of 70percent nitric acid at 50¡ã-60¡ãC. After addition the reaction mixture is kept at 55¡ãC. for one hour, then cooled and 50 mls. of ice water added. The resulting precipitate is recovered by filtering, water washed and dried to obtain 6-nitro-3,4-ethylenedioxybenzoic acid methyl ester, m.p. 115¡ã-118¡ãC.

The synthetic route of 20197-75-5 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Sandoz Inc.; US3931179; (1976); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

A stirred solution of compound 3 (0.1 mol) in ethanol (50 mL) was treated with the hydrazine hydrate (85%), under 90 C for 5 d. The sovlent was removed leaving oil which was dissolved in ethyl acetate (20 mL) and extracted with water (40 mL). After drying the organic layer with anhydrous Na2SO4 and evaporating the solvent under reduced pressure a solid appeared. The solid was recrystallized from ethanol to obtain the compound 6.

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Article; Sun, Juan; Lv, Peng-Cheng; Guo, Feng-Jiao; Wang, Xin-Yi; Han, Xiao-; Zhang, Yang; Sheng, Gui-Hua; Qian, Shao-Song; Zhu, Hai-Liang; European Journal of Medicinal Chemistry; vol. 81; (2014); p. 420 – 426;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.

To a solution of methyl 2,3-dihydrobenzo[6][l,4]dioxine-6-carboxylate (780 mg, 4.0 mmol) in acetic acid (3 mL) was added dropwise cone. HNO3 (4 mL) while keeping the temperature below 20 0 C and the resulting reaction mixture was warmed to room temperature. After stirring for 1 hr, the mixture was poured onto ice- water with vigorous stirring. The resulting white precipitate was collected by vacuum filtration and dried under reduced pressure to yield methyl 7-nitro-2,3-dihydrobenzo[6][l,4]dioxine-6- carboxylate (889 mg, 92percent). 1H NMR (DMSO-d6, 600 MHz) delta 7.64 (s, IH), 7.30 (s, IH), 4.41-4.38 (m, 4H), 3.80 (s, 3H); MS (ES+) m/z 240. 0 (M+H)+.

As the paragraph descriping shows that 20197-75-5 is playing an increasingly important role.

Reference£º
Patent; PRESIDENT AND FELLOWS OF HARVARD COLLEGE; WO2009/151561; (2009); A2;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem