An article Thiazolidinone/thiazole based hybrids – New class of antitrypanosomal agents WOS:000469159800022 published article about BIOLOGICAL EVALUATION; TRYPANOSOMA-BRUCEI; DRUG DISCOVERY; IN-VITRO; DERIVATIVES; AFRICAN; THIOSEMICARBAZONES; ANTICANCER; INHIBITORS; IDENTIFICATION in [Kryshchyshyn, Anna; Kaminskyy, Danylo; Lesyk, Roman] Danylo Halytsky Lviv Natl Med Univ, Dept Pharmaceut Organ & Bioorgan Chem, Pekarska 69, UA-79010 Lvov, Ukraine; [Karpenko, Oleksandr] Enamine Ltd, Chervonotkatska 78, UA-02094 Kiev, Ukraine; [Gzella, Andrzej] Poznan Univ Med Sci, Dept Organ Chem, Grunwaldzka 6, PL-60780 Poznan, Poland; [Grellier, Philippe] CNRS, UMR 7245, MNHN, Team BAMEE, CP 52,57 Rue Cuvier, F-75005 Paris, France; [Lesyk, Roman] Univ Informat Technol & Management Rzeszow, Dept Publ Hlth Dietet & Lifestyle Disorders, Fac Med, Sucharskiego 2, PL-35225 Rzeszow, Poland in 2019.0, Cited 67.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. Application In Synthesis of 1-(4-Nitrophenyl)ethanone
Different compounds have been investigated as potent drugs for trypanosomiasis treatment, but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as privileged structures and thiosemicarbazides cyclic analogs are well known scaffolds in novel antitrypanosomal agent design. We present here the design and synthesis of new hybrid molecules bearing thiazolidinone/thiazole cores linked by the hydrazone group with various molecular fragments. Structure optimization led to compounds with phenyl-indole or phenyl-imidazo[2,1-b][1,3,4]thiadiazole moieties showing excellent anti-trypanosomal activity towards Trypanosoma brucei brucei and Trypanosoma brucei gambiense. Biological study allowed identifying compounds with the submicromolar levels of IC50, good selectivity indexes and relatively low cytotoxicity upon human primary fibroblasts as well as low acute toxicity. (C) 2019 Elsevier Masson SAS. All rights reserved.
Application In Synthesis of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Kryshchyshyn, A; Kaminskyy, D; Karpenko, O; Gzella, A; Grellier, P; Lesyk, R or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem