3663-80-7, 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Example 12,3-dihydro-1,4-benzodioxine-2-carboxylic acid (0.38 mol; 68.51 g) and tetrahydrofuran (500 ml) were charged and contents were stirred at 20-25¡ã C. for 5-10 min to get a clear solution. N,N-carbonyl diimidazole (0.407 mol; 66.28 g) along with tetrahydrofuran (500 ml) was added to the solution and stirring continued at 20-25¡ã C. for 2 hr to obtain solution A.In another round bottom flask, 6,7-dimethoxy-2-(piperazin-1-yl)quinazolin-4-amine (0.346 mol; 100 g) and tetrahydrofuran (1000 ml) were charged and stirred at 26-28¡ã C. for 5-10 min to obtain a slurry.Solution A was added dropwise within 2-2.5 hr at 25-28¡ã C. to the slurry.The reaction was monitored by HPLC.To the resulting clear reaction mass charcoal was added and contents were stirred at 26-28¡ã C. for 45 min.The contents were filtered through celite and washed with tetrahydrofuran.The solvent was distilled out at 35¡ã C. under reduced pressure to obtain solid residue.Acetone (1000 ml) was added to the solid and contents were refluxed for 2 hr.On cooling to 25-28¡ã C., the slurry was filtered, washed with acetone and dried at 60¡ã C. under reduced pressure to obtain 110 g of doxazosin base (HPLC purity -99.4percent).
3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various.
Reference£º
Patent; CIPLA LIMITED; US2012/41199; (2012); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem