It is a common heterocyclic compound, the benzodioxans compound, (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine, cas is 17413-10-4 its synthesis route is as follows.,17413-10-4
General procedure: Following procedure B as those described in Schemes 1 or 2 compounds of formulae (Ia) or (Ib) can be prepared in the conditions described below: The appropriate amine (ex: 1 -(2,3-dihydro- 1 ,4-benzodioxin-6-yl)methanamine) (1 eq) was added to a mixture of 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide chloridric salt (3 eq), diisopropylethylamine (5 eq) and the appropriate acid (VIa) or (VIb) (ex: 4-((7-chloroisoquinolin-1-yl)amino)benzoic acid) (1 eq) in dimethylformamide and the mixture was heated under microwave conditions (600 W) for 10 mm. After consumption of starting materials, the reaction mixture was diluted with water and extracted in ethyl acetate (2x). The combined organic extract was washed with brine solution followed by water and the resulting organic layer was dried over anhydrous sodium sulphate and concentrated. Thecrude was purified by flash column chromatography (dichloromethane/methanol) to afford desired amide compounds (VIla) or (VIIb) (ex: 4-((7-chloroisoquinolin-1-yl)amino)-N- ((2,3-dihydrobenzo [b] [1 ,4]dioxin-6-yl)methyl)benzamide (Example 5).
With the complex challenges of chemical substances, we look forward to future research findings about (2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)methanamine
Reference£º
Patent; MINORYX THERAPEUTICS S.L.; GARCIA COLLAZO, Ana Maria; MARTINELL PEDEMONTE, Marc; CUBERO JORDA, Elena; BARRIL ALONSO, Xavier; RODRIGUEZ PASCAU, Laura Pilar; (136 pag.)WO2018/122746; (2018); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem