Wang, Rui; Ranganathan, Srivathsan V.; Haruehanroengra, Phensinee; Mao, Song; Scalabrin, Matteo; Fabris, Daniele; Chen, Alan; Liu, Hehua; Hassan, Abdalla E. A.; Gan, Jianhua; Sheng, Jia published the article 《Construction and structure studies of DNA-bipyridine complexes as versatile scaffolds for site-specific incorporation of metal ions into DNA》. Keywords: DNA bipyridine complex metal ion binding; DNA material; DNA scaffold; click reaction; metallic DNA; propargyl-DNA.They researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).SDS of cas: 1762-34-1. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1762-34-1) here.
The facile construction of metal-DNA complexes using ‘Click’ reactions is reported here. A series of 2′-propargyl-modified DNA oligonucleotides were initially synthesized as structure scaffolds and were then modified through ‘Click’ reaction to incorporate a bipyridine ligand equipped with an azido group. These metal chelating ligands can be placed in the DNA context in site-specific fashion to provide versatile templates for binding various metal ions, which are exchangeable using a simple EDTA washing-and-filtration step. The constructed metal-DNA complexes were found to be thermally stable. Their structures were explored by solving a crystal structure of a propargyl-modified DNA duplex and installing the bipyridine ligands by mol. modeling and simulation. These metal-DNA complexes could have wide applications as novel organometallic catalysts, artificial RNases, and potential metal delivery systems.
As far as I know, this compound(1762-34-1)SDS of cas: 1762-34-1 can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.