COA of Formula: C8H7NO3. Authors Yang, LL; Chen, Y; He, JL; Njoya, EM; Chen, JJ; Liu, SY; Xie, CQ; Huang, WZ; Wang, F; Wang, ZY; Li, YZ; Qian, S in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Yang, Lingling; Chen, Yang; Chen, Jianjun; Liu, Siyan; Xie, Congqiang; Huang, Wenze; Wang, Zhouyu; Qian, Shan] Xihua Univ, Sch Food & Bioengn, Dept Pharmaceut Engn, Chengdu 610039, Sichuan, Peoples R China; [He, Junlin; Li, Yuzhi] Chengdu Univ Tradit Chinese Med, Coll Pharm, Key Lab Systemat Res Dev & Utilizat Chinese Med R, Chengdu 610091, Sichuan, Peoples R China; [Njoya, Emmanuel Mfotie; Wang, Fei] Chinese Acad Sci, Chengdu Inst Biol, Key Lab Nat Med & Clin Translat, Chengdu 610041, Sichuan, Peoples R China in 2019.0, Cited 38.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
Indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO) are constitutively overexpressed in many types of cancer cells and exert important immunosuppressive functions. In this article, a series of 4,6-substituted-1H-indazole derivatives were synthesized and evaluated the inhibitory activities against IDO1 and TDO, as well as their structure-activity relationships (SARs). Among these, compound 35 displayed the most IDO1 inhibitory potency with an IC50 value of 0.74 mu M in an enzymatic assay and 1.37 mu M in HeLa cells. Quantitative analysis of the Western blot results indicated that 35 significantly decreased the INF gamma-induced IDO1 expression in a concentration-dependent manner. In addition, 35 showed promising TDO inhibition with an IC50 value of 2.93 mu M in the enzymatic assay and 7.54 mu M in A172 cells. Moreover, compound 35 exhibited in vivo antitumor activity in the CT26 xenograft model. These findings suggest that 1H-indazole derivative 35 is a potent IDO1/TDO dual inhibitor, and has the potential to be developed for IDO1/TDO-related cancer treatment.
COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Yang, LL; Chen, Y; He, JL; Njoya, EM; Chen, JJ; Liu, SY; Xie, CQ; Huang, WZ; Wang, F; Wang, ZY; Li, YZ; Qian, S or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem