Computed Properties of C8H7NO3. In 2019.0 MEDCHEMCOMM published article about MYCOBACTERIUM-TUBERCULOSIS; RESISTANT TUBERCULOSIS; BIOLOGICAL EVALUATION; HYDRAZIDE-HYDRAZONES; DRUGS; DESIGN; TB; DISEASE; TRENDS in [Beteck, Richard M.; Khanye, Setshaba D.] Rhodes Univ, Dept Chem, Fac Sci, ZA-6140 Grahamstown, South Africa; [Seldon, Ronnett] Univ Cape Town, Dept Chem, Drug Discovery & Dev Ctr H3 D, ZA-7701 Rondebosch, South Africa; [Jordaan, Audrey; Warner, Digby F.] Univ Cape Town, Dept Pathol, SAMRC NHLS UCT Mol Mycobacteriol Res Unit, ZA-7925 Observatory, South Africa; [Warner, Digby F.] Univ Cape Town, Inst Infect Dis & Mol Med, ZA-7952 Observatory, South Africa; [Warner, Digby F.] Univ Cape Town, Wellcome Ctr Clin Infect Dis Res Africa, ZA-7925 Observatory, South Africa; [Hoppe, Heinrich C.] Rhodes Univ, Dept Biochem & Microbiol, Fac Sci, ZA-6140 Grahamstown, South Africa; [Hoppe, Heinrich C.; Laming, Dustin; Khanye, Setshaba D.] Rhodes Univ, Ctr Chem & Biomed Res, ZA-6140 Grahamstown, South Africa; [Legoabe, Lesetja J.] North West Univ, Ctr Excellence Pharmaceut Sci, ZA-2520 Potchefstroom, South Africa; [Khanye, Setshaba D.] Rhodes Univ, Fac Pharm, ZA-6140 Grahamstown, South Africa in 2019.0, Cited 41.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Herein, we propose novel quinolones incorporating an INH moiety as potential drug templates against TB. The quinolone-based compounds bearing an INH moiety attached via a hydrazide-hydrazone bond were synthesised and evaluated against Mycobacterium tuberculosis H37Rv (MTB). The compounds were also evaluated for cytotoxicity against HeLa cell lines. These compounds showed significant activity (MIC90) against MTB in the range of 0.2-8 mu M without any cytotoxic effects. Compounds 10 (MIC90; 0.9 mu M), 11 (MIC90; 0.2 mu M), 12 (MIC90; 0.8 mu M) and compound 15 (MIC90; 0.8 mu M), the most active compounds in this series, demonstrate activities on par with INH and superior to those reported for the fluoroquinolones. The SAR analysis suggests that the nature of substituents at positions -1 and -3 of the quinolone nucleus influences anti-MTB activity. Aqueous solubility evaluation and in vitro metabolic stability of compound 12 highlights favourable drug-like properties for this compound class.
Computed Properties of C8H7NO3. Welcome to talk about 100-19-6, If you have any questions, you can contact Beteck, RM; Seldon, R; Jordaan, A; Warner, DF; Hoppe, HC; Laming, D; Legoabe, LJ; Khanye, SD or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem