With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.3663-80-7,2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid,as a common compound, the synthetic route is as follows.
To a solution of 1 ,4-benzodioxan-2-carboxylic acid (0.216 g, 1.2 mmol) in N, N- dimethylformamide (5.0 mL) were added 2,2-diphenylethanamine (0.197 g, 1.0 mmol), 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (0.186 g, 1.2 mmol) and 1- hydroxybenzotriazole (0.162 g, 1.2 mmol). The resulting mixture was stirred at ambient temperature for 16 h. To the above mixture was added ethyl acetate (100 ml_), the resultant solution was washed with 2 N citric acid (50 ml_), saturated sodium bicarbonate (50 ml_) and brine (50 ml_). The organic layer was dried over anhydrous sodium sulfate, then filtered and concentrated to give the crude product. The crude product was recrystalized from ether and hexane to yield lambda/-(2,2-diphenylethyl)-2,3- dihydro-1 ,4-benzodioxine-2-carboxamide (0.326 g, 91percent) as a colorless solid: 1H NMR (300 MHz, CDCI3) 5 7.33-7.11 (m, 10H), 6.89-6.68 (m, 4H), 6.49 (s, 1 H), 4.59 (dd, J = 6.6, 2.7 Hz, 1 H), 4.39 (dd, J = 11.3, 2.7 Hz, 1 H), 4.17-3.97 (m, 3H), 3.90-3.78 (m, 1H); 13C NMR (75 MHz, CDCI3) delta 167.1 , 143.2, 141.4, 141.3, 128.7, 128.7, 128.0, 127.9, 126.9, 122.2, 121.9, 117.6, 117.0, 73.2, 65.0, 50.5, 43.2; MS (ES+) m/z 382.1 (M + 23), 360.1 (M + 1 )., 3663-80-7
3663-80-7 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid 2735450, abenzodioxans compound, is more and more widely used in various.
Reference£º
Patent; XENON PHARMACEUTICALS INC.; WO2008/106633; (2008); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem