With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.29668-44-8,2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a solution of 2-nitro-benzaldehyde 1a,b or benzaldehyde 4a,b (20 mmol) in methanol (15 mL) was added dropwise solution of hydroxylamine hydrochloride (40 mol) in water (10 mL) at room temperature in 30 min. Aqueous solution of sodium hydroxide (0.4 mol) was then added dropwise to the solution and the sulting mixture was stirred for 30-60 min at room temperature. Afterwards, solvent was removed under reduced pressure, the residue was quenched in crushed ice/water (10 mL) and the pH was adjusted to ~ 4 with acetic acid 50 %. The formed precipitate was isolated, washed with cold water (20 mL) and n-hexane (30 mL), and dried at 50C to afford corresponding oxime derivatives 2a,b or 5a,b, which were used for the next step without further purification.
29668-44-8 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde 248127, abenzodioxans compound, is more and more widely used in various.
Reference£º
Article; Le-Nhat-Thuy, Giang; Dinh, Thuy Van; Pham-The, Hai; Nguyen Quang, Hung; Nguyen Thi, Nga; Dang Thi, Tuyet Anh; Hoang Thi, Phuong; Le Thi, Tu Anh; Nguyen, Ha Thanh; Nguyen Thanh, Phuong; Le Duc, Trung; Nguyen, Tuyen Van; Bioorganic and Medicinal Chemistry Letters; vol. 28; 23-24; (2018); p. 3741 – 3747;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem