With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.2879-20-1,1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone,as a common compound, the synthetic route is as follows.
General procedure: In a typical reaction, acetophenone (0.4 mmol) and I2 (0.4 mmol)was stirred in DMSO (1 mL) at 60C for 6 h. After the mixture was cooled to room temperature and subsequently, 2-methylindol(0.2 mmol), sesamol (0.2 mmol) were added to the reaction solutionalong with PTSA (0.04 mmol, 20 mol %). The mixture was then stirred at 80C for 3 h. At the end of the reaction,water (10 mL)was added and then extracted with EtOAc (310 mL). The acquired organic phase was combined and dried with anhydrous Na2SO4.The volatile components were removed under reduced pressure.The product was obtained by isolation with preparative TLC (elutingsolution: petroleum ether/dichloromethane1/2 (v/v)). Tests for substrate scope and the reaction of using other nucleophiles were all performed according to an analogous procedure. Whena 10 mmol scale reaction was conducted, the product was isolated by silica column chromatography.
2879-20-1 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone 76143, abenzodioxans compound, is more and more widely used in various.
Reference£º
Article; Cheng, Cheng; Liu, Changhui; Gu, Yanlong; Tetrahedron; vol. 71; 42; (2015); p. 8009 – 8017;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem