With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.20197-75-5,Methyl 1,4-Benzodioxan-6-carboxylate,as a common compound, the synthetic route is as follows.
To a solution of 2a (1.16 g, 6.0 mmol) in EtOH (30 mL) was added hydrazine hydrate (2.91 mL, 60 mmol) and the mixture was heated at reflux for 2 days. After cooling to room temperature pure crystals are formed, collected by filtration and washed several times with EtOH to give compound 3a (0.87 g, 75%) as a light yellow solid. 1H NMR (DMSO-d6, 500 MHz): delta [ppm] = 4.28 (2H, m), 4.30 (2H, m), 6.89 (1H, d, J = 8.4 Hz), 7.30 (1H, dd, J = 8.3 Hz, J = 2.1 Hz), 7.33 (1H, d, J = 2.1 Hz). 13C NMR (DMSO-d6, 125 MHz): delta [ppm] = 65.9, 66.3, 117.9, 118.6, 121.9, 127.5, 145.2, 148.6, 169.6. EI-MS: m/z 194 (M+)., 20197-75-5
20197-75-5 Methyl 1,4-Benzodioxan-6-carboxylate 3802178, abenzodioxans compound, is more and more widely used in various.
Reference£º
Article; Lo Monte, Fabio; Kramer, Thomas; Gu, Jiamin; Brodrecht, Martin; Pilakowski, Johannes; Fuertes, Ana; Dominguez, Juan Manuel; Plotkin, Batya; Eldar-Finkelman, Hagit; Schmidt, Boris; European Journal of Medicinal Chemistry; vol. 61; (2013); p. 26 – 40;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem