An article Catalytic Enantioselective Synthesis of Difluorinated Alkyl Bromides WOS:000598512400010 published article about HYPERVALENT IODINE REAGENTS; FLUORINATION; SPIROLACTONIZATION; ALKENES; DEAROMATIZATION; OXIDATION; SYSTEMS; DESIGN; ROUTE; CF2 in [Levin, Mark D.; Ovian, John M.; Read, Jacquelyne A.; Jacobsen, Eric N.] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA; [Read, Jacquelyne A.; Sigman, Matthew S.] Univ Utah, Dept Chem, Salt Lake City, UT 84112 USA in 2020.0, Cited 78.0. Safety of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
We report an iodoarene-catalyzed enantioselective synthesis of beta,beta-difluoroalkyl bromide building blocks. The transformation involves an oxidative rearrangement of alpha-bromostyrenes, utilizing HF-pyridine as the fluoride source and m-CPBA as the stoichiometric oxidant. A catalyst decomposition pathway was identified, which, in tandem with catalyst structure-activity relationship studies, facilitated the development of an improved catalyst providing higher enantioselectivity with lower catalyst loadings. The versatility of the difluoroalkyl bromide products was demonstrated via highly enantiospecific substitution reactions with suitably reactive nucleophiles. The origins of enantioselectivity were investigated using computed interaction energies of simplified catalyst and substrate structures, providing evidence for both CH-pi and pi-pi transition state interactions as critical features.
Safety of 1-(4-Nitrophenyl)ethanone. Welcome to talk about 100-19-6, If you have any questions, you can contact Levin, MD; Ovian, JM; Read, JA; Sigman, MS; Jacobsen, EN or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem