2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.
Compound 1 was prepared according to Scheme 5,shown below. The coupling of 2,3-dihydrobenzo[b] [1,4]dioxine-2-carboxylic acid and hydrazinecarbothioamide via an addition reaction and subsequent dehydration was performedin the presence of hydroxybenzotriazole (HOSt), 1 -ethyl-3-(3-dimethylaminopropyl)carbodiimide, and triethylamine (TEA) dissolved in tetrahydroffiran (THF). A cyclization reaction of 2-(2,3-dihydrobenzo[b] [1 ,4]dioxine-2- carbonyl)hydrazinecarbothioamide was performed in an aqueous solution of NaOH (95percent) to afford the thiol intermediate. Finally, the ttle compound was formed by treatingthe thiol with sulfuric acid in acetic acid.The title compound was prepared by Shanghai ChemPartner according to Scheme 5. Purity by analytical HPLC: 96percent. HR-MS (ESI+): Calcd. Mw for C2QH,6N60452 469.0675. found mlz 469.0748 [M+H]. The purity of compound 1 was determined using a 1200 Infinity Series analytical HPLC system (Agilent) operating at a flow rate of 0.9 mE/mm, using a linear gradient of 2-98percent acetonitrile in water (both solvents containing 0.1percent v/v of ammonium hydroxide) over 2 mm, on a Waters Acquity UPEC I3EH C18 colunm (1.7 jtm, 2.1×50 mm) set at 60¡ã C., 3663-80-7
With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
Reference£º
Patent; The General Hospital Corporation; ZAPOL, Warren M.; BLOCH, Kenneth D.; NAKAGAWA, Akito; LUI, Francine E.; FREEDMAN, Revital; (38 pag.)US2016/331782; (2016); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem