Vodnala, N; Gujjarappa, R; Hazra, CK; Kaldhi, D; Kabi, AK; Beifuss, U; Malakar, CC in [Vodnala, Nagaraju; Gujjarappa, Raghuram; Kaldhi, Dhananjaya; Kabi, Arup. K.; Malakar, Chandi C.] Natl Inst Technol Manipur, Dept Chem, Imphal 795004, Manipur, India; [Hazra, Chinmoy K.] Korea Adv Inst Sci & Technol, Dept Chem, Daejeon 305701, South Korea; [Beifuss, Uwe] Univ Hohenheim, Inst Chem, Garbenstr 30, D-70599 Stuttgart, Germany published Copper-Catalyzed Site-Selective Oxidative C-C Bond Cleavage of Simple Ketones for the Synthesis of Anilides and Paracetamol in 2019, Cited 70. Product Details of 100-19-6. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
A copper-catalyzed approach for the N-acylation of anilines with acetone and acetophenones via C-C bond cleavage is described. Under the developed conditions both CHCl3 and CH2Cl2 were identified as potential C1-source to promote the transformation. The reaction features a site selective C-C bond cleavage to install the amide moieties with high functional-group compatibility and wide substrate scope. The developed method avoids the use of sensitive and narcotic agents. The method also represents an excellent complement to the previous protocols with lower E-factor (13.91 mg/1 mg) than current industrially used method (E-factor 17.54 mg/1 mg). The developed approach has also been extended for the effective preparation of pyridine derivatives and paracetamol in gram scale. The course of the reaction was monitored by H-1 NMR as a preliminary investigation of the reaction mechanism.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem