Recently I am researching about BISINDOLE, Saw an article supported by the Higher Education Commission, PakistanHigher Education Commission of Pakistan [59/PAS/3437]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. COA of Formula: C8H7NO3
beta-Glucuronidase enzyme is a tetrameric glycoprotein present in microsomes and lysosomes of many organs, and body fluids. Over-expression of this enzyme is observed in several melanomas and carcinomas. Therefore, it has been identified as a target for the treatment of several pathological conditions. In this regard, carbazole linked 1,2,3-triazoles (1-27) were synthesized according to our previous report, and evaluated for their in vitro beta-glucuronidase inhibitory activities. Compounds 7-10, 17-18, 20, and 22-27 showed potent activities with IC50 values between 0.55-32.5 mu M, as compared to the standard, D-saccharic acid 1,4-lactone (IC50=45.75 +/- 2.16 mu M). All active compounds were found to be non-cytotoxic against mouse fibroblast 3T3 cell line. Compounds 20, 22, 23, 25, 26, and 27 were subjected to enzyme kinetic studies for the determination of their modes of inhibition, and dissociation constants Ki. Compounds 23, 25, and 26 were also studied for their mode of inhibition by using molecular docking methods.
COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Shaikh, NN; Iqbal, S; Syed, N; Khan, MA; Moin, ST; Choudhary, MI; Basha, FZ or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem