Heterocyclic Building Blocks-benzodioxan

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ) is researched.SDS of cas: 1762-34-1.Pan, Yao; Zhang, Nan; Liu, Chun-Hua; Fan, Shilu; Guo, Song; Zhang, Zhi-Ming; Zhu, Yuan-Yuan published the article 《Boosting Photocatalytic Activities for Organic Transformations through Merging Photocatalyst and Transition-Metal Catalyst in Flexible Polymers》 about this compound( cas:1762-34-1 ) in ACS Catalysis. Keywords: merging photocatalyst Transition Metal catalyst flexible polymer. Let’s learn more about this compound (cas:1762-34-1).

The merger of photocatalysis and transition-metal catalysis is of particular interest to develop useful and challenging synthetic methodologies. The catalytic activities of conventional dual-catalytic systems, however, are limited by the low synergistic efficiency between discrete catalytic centers due to their long average distance in solution Herein we carefully decorated Ir(III) photosensitizers and Ni(II) transition-metal catalyst into flexible polymers to afford two polymer-supported dual catalysts (P1-Ni and P2-Ni). These polyelectrolyte-type metallopolymers assembled into spherical polymer particles in some polar solvents. Their unique mol. and assembled structure contributed to shortening the distance between catalytic centers and increasing the local catalysts′ concentration within the catalyst, thereby greatly facilitating their electron, energy, and organic radical transfers during the catalytic cycles. The enhanced energy interaction and matched redox potential between two catalytic centers within the polymer were confirmed by steady- and transient-state luminescent spectra and cyclic voltammetry. These features enable them in catalyzing challenging organic transformations that involve efficiently incorporated photocatalytic and transition-metal catalytic cycles. We demonstrated that these two catalysts were highly effective in catalyzing C-S cross-coupling, C-O functionalized, C-N cross-coupling, and C-C cross-coupling reactions with broad substrate scopes and low catalyst loadings with turnover numbers of ~3100, ~1500, ~1400, and ~500, resp. This work provides a general methodol. to merge photosensitizer and transition-metal catalyst in a flexible polymer for significantly boosting the catalytic activity.

After consulting a lot of data, we found that this compound(1762-34-1)SDS of cas: 1762-34-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Synthetic Route of C12H12N2. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Chemical sensors based on nano-sized lanthanide-grafted periodic mesoporous organosilica hybrid materials. Author is Kaczmarek, Anna M.; Van Der Voort, Pascal.

In this work authors introduce the use of nano-sized (50-70 nm) lanthanide-grafted periodic mesoporous organosilicas for both metal ion sensing and solvent sensing. For this study a PMO constructed from the N,N-bis(trimethoxysilylpropyl)-2,6-pyridine dicarboxamide linker and tetra-Et orthosilicate (at a 5 : 95 ratio) was employed. This material was grafted with Eu3+, Tb3+ or a mixture of Eu3+-Tb3+ chloride salts to obtain strongly emitting nano-sized luminescence materials. To further enhance the luminescence properties of the materials two different co-ligands were used – 1,10-phenanthroline (phen) and 5,5′-dimethyl-2,2′-dipyridyl (bpy). The luminescence properties of the developed series of hybrid materials were studied in detail in the solid-state and after dispersing in water. The materials were investigated for their use as ion sensors, with the Eu3+ and Tb3+ phen and bpy co-grafted materials showing selective “”turn on”” fluorescence for Pb2+ and Cr3+ ions (at a 10 ppm concentration of the ions). The Eu3+-Tb3+ co-grafted materials showed solvatochromism and could be used as a solvent sensor to distinguish between protic and aprotic solvents.

After consulting a lot of data, we found that this compound(1762-34-1)Synthetic Route of C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer, published in 2020-11-28, which mentions a compound: 1762-34-1, Name is 5,5′-Dimethyl-2,2′-bipyridine, Molecular C12H12N2, Electric Literature of C12H12N2.

In this study, we newly designed and synthesized a small library of ten structurally related C,N-cyclometalated ruthenium(II) complexes containing various pyridine-functionalized NHC ligand and chelating bipyridyl ligands (e.g., 2,2′-bipyridine, 5,5′-dimethyl-2,2′-bipyridine, and 1,10-phenanthroline (phen)). The complexes were well characterized by NMR, electrospray ionization-mass spectrometry, and single-crystal X-ray structure analyses. Among the new ruthenium(II) derivatives, we identified that the complex Ru8 bearing bulky moieties (i.e., phen and pentamethyl benzene) had the most potent cytotoxicity against all tested cancer cell lines, generating dose- and cell line-dependent IC50 values at the range of 3.3-15.0μM. More significantly, Ru8 not only efficiently inhibited the metastasis process against invasion and migration of tumor cells but also exhibited potent antivascular effects by suppressing HUVEC cells migration and tube formation in vitro and blocking vessel generation in vivo (chicken chorioallantoic membrane model). In a metastatic A2780 tumor xenograft-bearing mouse model, administration of Ru8 outperformed antimetastatic agent NAMI-A and clin. approved cisplatin in terms of antitumor efficacy and inhibition of metastases to other organs. Overall, these data provided compelling evidence that the new cyclometalated ruthenium complex Ru8 is an attractive agent because of synergistically suppressing bulky tumors and metastasized tumor nudes. Therefore, the complex Ru8 deserves further investigations.

After consulting a lot of data, we found that this compound(1762-34-1)Electric Literature of C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called New Organometallic Ruthenium(II) Compounds Synergistically Show Cytotoxic, Antimetastatic and Antiangiogenic Activities for the Treatment of Metastatic Cancer, Author is Wang, Yuchen; Jin, Jiahui; Shu, Liwei; Li, Tongyu; Lu, Siming; Subarkhan, Mohamed Kasim Mohamed; Chen, Chao; Wang, Hangxiang, which mentions a compound: 1762-34-1, SMILESS is CC1=CN=C(C=C1)C1=NC=C(C)C=C1, Molecular C12H12N2, Formula: C12H12N2.

In this study, we newly designed and synthesized a small library of ten structurally related C,N-cyclometalated ruthenium(II) complexes containing various pyridine-functionalized NHC ligand and chelating bipyridyl ligands (e.g., 2,2′-bipyridine, 5,5′-dimethyl-2,2′-bipyridine, and 1,10-phenanthroline (phen)). The complexes were well characterized by NMR, electrospray ionization-mass spectrometry, and single-crystal X-ray structure analyses. Among the new ruthenium(II) derivatives, we identified that the complex Ru8 bearing bulky moieties (i.e., phen and pentamethyl benzene) had the most potent cytotoxicity against all tested cancer cell lines, generating dose- and cell line-dependent IC50 values at the range of 3.3-15.0μM. More significantly, Ru8 not only efficiently inhibited the metastasis process against invasion and migration of tumor cells but also exhibited potent antivascular effects by suppressing HUVEC cells migration and tube formation in vitro and blocking vessel generation in vivo (chicken chorioallantoic membrane model). In a metastatic A2780 tumor xenograft-bearing mouse model, administration of Ru8 outperformed antimetastatic agent NAMI-A and clin. approved cisplatin in terms of antitumor efficacy and inhibition of metastases to other organs. Overall, these data provided compelling evidence that the new cyclometalated ruthenium complex Ru8 is an attractive agent because of synergistically suppressing bulky tumors and metastasized tumor nudes. Therefore, the complex Ru8 deserves further investigations.

After consulting a lot of data, we found that this compound(1762-34-1)Formula: C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Category: benzodioxans. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Ultrafine palladium nanoparticles stabilized in the porous liquid of covalent organic cages for photocatalytic hydrogen evolution. Author is Zhang, Jian-Hua; Wei, Mei-Juan; Lu, Yu-Lin; Wei, Zhang-Wen; Wang, Hai-Ping; Pan, Mei.

Soluble covalent organic cages (COCs) were designed to comprise cryptand inner cavities and multiple metal-chelating sites on windows. The porous liquid formed by well-dispersed COCs in solution proves to be an excellent stabilizer for ultrafine palladium nanoparticles with a critical size of 1-3 nm using NaBH4 or methanol as a reductant. When transferring palladium nanoparticles stabilized in the porous liquid of COCs onto carbon nitride (g-C3N4), an efficient heterogeneous photocatalyst could be obtained to possess high catalytic activity for hydrogen evolution from water with long-term durability. This provides prospects for the application of porous liquids in various fields by combining advantages of homogeneous and heterogeneous attributes together.

After consulting a lot of data, we found that this compound(1762-34-1)Category: benzodioxans can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 1762-34-1, is researched, SMILESS is CC1=CN=C(C=C1)C1=NC=C(C)C=C1, Molecular C12H12N2Journal, Wuji Huaxue Xuebao called High sensitivity and selectivity of aminoantipyrine schiff base for recognition of Fe2+, Author is Chen, Sheng-tian; Zhang, Yu; Zhao, Jian-ying; Ma, Kui-rong; Li, Rong-qing; Tang, Guo-dong, the main research direction is chemosensor aminoantipyrine schiff base iron.Computed Properties of C12H12N2.

An aminoantipyrine based chemosensor, (E)-1,5-dimethyl-4-((2-(4-methylpyridin-2-yl)pyridin-4-yl)methyleneamino)-2-phenyl-1,2-dihydropyrazol-3-one(L), derived from 4-aminoantipyrine and 2-(4-methylpyridin-2-yl) isonicotinaldehyde, was synthesized and the optical and metal sensing properties were investigated. The chemosensor L showed a selective colorimetric sensing ability for Fe2+ by changing colors from pale yellow to deep red in water-ethanol (9:1, V/V) medium, which facilitates the ‘naked-eye’ recognition of Fe2+ from other examined metal ions. The complex stoichiometry of Fe2+ to L(1:3,[FeL3]2+) was obtained by Job’s method. The association constant was determined to be 3.70×1021 L3·mol-3. The present results indicate that the chemosensor L could be used as a selective, sensitive colorimetric sensor for Fe2+.

After consulting a lot of data, we found that this compound(1762-34-1)Computed Properties of C12H12N2 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria, published in 2020-02-29, which mentions a compound: 1762-34-1, mainly applied to antibacterial copper silica nanoparticle; Antibacterial activity; Copper; Electrochemistry; Mesoporous silica; ROS; SBA-15, Quality Control of 5,5′-Dimethyl-2,2′-bipyridine.

A series of copper-functionalized SBA-15 (Santa Barbara Amorphous) materials containing the ligands triethoxysilylpropylmaleamic acid (maleamic) or triethoxy-3-(2-imidazolin-1-yl)propylsilane (imidazoline) have been prepared The nanostructured silica-based systems SBA-maleamic, SBA-imidazoline, SBA-maleamic-Cu and SBA-imidazoline-Cu were characterized by several methods observing that the functionalization took place mainly inside the pores of the mesoporous system. The antimicrobial behavior of the synthesized materials against Staphylococcus aureus and Escherichia coli was tested observing a very potent activity of the copper-functionalized systems (min. inhibitory concentration (MIC) and min. bactericidal concentration (MBC) values for SBA-maleamic-Cu of ca. 31.25 μg/mL, which correspond with ca. 1.13 μg/mL of Cu). A study of the oxidative stress promoted by the synthesized materials showed that the SBA-maleamic-Cu and the SBA-imidazoline-Cu were able to increase the reactive oxygen species (ROS) production in S. aureus by 427% and 373%, resp., while this increase was slightly lower in E. coli (387 and 324%, resp.). Furthermore, an electrochem. study was carried out in order to determine if these materials interact with lysine or alanine to validate a potential antimicrobial mechanism based on the inhibition of the synthesis of the peptidoglycan of the bacterial wall. Finally, these studies were also performed to determine the potential interaction of the copper-containing materials with glutathione in order to assess if they are able to perturb the metabolism of this tripeptide.

Although many compounds look similar to this compound(1762-34-1)Quality Control of 5,5′-Dimethyl-2,2′-bipyridine, numerous studies have shown that this compound(SMILES:CC1=CN=C(C=C1)C1=NC=C(C)C=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

Recommanded Product: 2160535-56-6. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: (R)-N-((R)-(5-(Diphenylphosphanyl)-9,9-dimethyl-9H-xanthen-4-yl)(4-methoxyphenyl)methyl)-2-methylpropane-2-sulfinamide, is researched, Molecular C39H40NO3PS, CAS is 2160535-56-6, about Gold-Catalyzed Asymmetric Intramolecular Cyclization of N-Allenamides for the Synthesis of Chiral Tetrahydrocarbolines. Author is Wang, Yidong; Zhang, Peichao; Di, Xiaoyu; Dai, Qiang; Zhang, Zhan-Ming; Zhang, Junliang.

Highly enantioselective gold-catalyzed intramol. cyclization of N-allenamides was implemented by utilizing a designed chiral sulfinamide phosphine ligand (PC-Phos) [e.g., allenamide I → tetrahydrocarboline II (99%, 96% ee) in presence of Me2S.AuCl, AgNTf2 and ligand III in CH2Cl2 at -50°]. This represents the first example of highly enantioselective intramol. cyclization of N-allenamides. The practicality of this reaction was validated in the total synthesis of (R)-desbromoarborescidine A and formal synthesis of (R)-desbromoarborescidine C and (R)-deplancheine. Moreover, the catalyst system PC-Phos/AuNTf2 proved to be specifically efficient to promote the desymmetrization of N-allenamides in excellent yields with satisfactory ee values.

After consulting a lot of data, we found that this compound(2160535-56-6)Recommanded Product: 2160535-56-6 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

HPLC of Formula: 1762-34-1. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 5,5′-Dimethyl-2,2′-bipyridine, is researched, Molecular C12H12N2, CAS is 1762-34-1, about Synthesis, structures, thermal behaviour, luminescence and magnetic properties of lanthanide complexes constructed from 2,6-dimethylbenzoic acid and 5,5′-dimethyl-2,2′-bipyridine.

Six new lanthanide complexes, with the formula [La(2,6-DMBA)3(5,5′-DM-2,2′-bipy)(H2O)]2 (1) and [Ln(2,6-DMBA)3(5,5′-DM-2,2′-bipy)]2 (Ln = Tb(2), Dy(3), Ho(4), Pr(5), Nd(6)) (2,6-DMBA = 2,6-dimethylbenzoate, 5,5′-DM-2,2′-bipy = 5,5′-dimethyl-2,2′-bipyridine) have been successfully synthesized and characterized. These title complexes have three different structural types. The structure of complex 1(type I) contains coordination water mols., and the coordination number is 8. The coordination numbers of complexes 2-4 and 5-6 are 8 and 9, showing a distorted square antiprism geometry and distorted monocapped square anti-prismatic geometry, resp. However they have the same general formula and they can be all assembled into the same 1D, 2D supramol. structures via the C-H···O hydrogen bonding interactions, which is interesting in previous lanthanide complexes. The complexes were analyzed by TG-DSC/FTIR. In addition, the visible light luminescence experiments of Tb (III) complex was carried out, and the characteristic luminescence behavior of strong green color was shown. And the fluorescence lifetime and intrinsic quantum yield were calculated The magnetic properties of complexes 2-4 were also studied, and the results showed that complex 3 and complexes 2, 4 have ferromagnetic interactions and antiferromagnetic interactions, resp.

After consulting a lot of data, we found that this compound(1762-34-1)HPLC of Formula: 1762-34-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ) is researched.SDS of cas: 1762-34-1.Mautner, Franz A.; Bierbaumer, Florian; Gyurkac, Marcell; Fischer, Roland C.; Torvisco, Ana; Massoud, Salah S.; Vicente, Ramon published the article 《Synthesis and characterization of Lanthanum(III) complexes containing 4,4,4-trifluoro-1-(naphthalen-2yl)butane-1,3-dionate》 about this compound( cas:1762-34-1 ) in Polyhedron. Keywords: lanthanum fluoronaphthyldiketonate bipyridine terpyridine complex preparation crystal structure; optimized mol structure lanthanum fluoronaphthyldiketonate bipyridine terpyridine complex. Let’s learn more about this compound (cas:1762-34-1).

Seven La(III) complexes with the β-diketonate anion 4,4,4-trifluoro-1-(2-naphthyl)butane-1,3-dionato(1-) (ntfa) have been synthesized, namely: [La(ntfa)3(MeOH)3] (1a), [La(ntfa)3(H2O)2(EtOH)](EtOH) (1b), [La(ntfa)3(bipy)2] (2), [La(ntfa)3(Me2bipy)] (3), [La(ntfa)3(terpy)] (4), (NEt4)[La(ntfa)4] (5) and [La(ntfa)4Na(H2O)(EtOH)(Methyl-β-naphthylketone)] (6), where bipy = bipyridine, Me2bipy = 5,5′-dimethyl-bipyridine, terpy = terpyridine, NEt4+ = tetraethylammonium ion and structurally characterized. The tris-β-diketonate compounds 1a,b, 2-4 form neutral monomeric complexes with C. N. nine for 1a, 1b and 4, eight for 3, and ten in case of 2. The tetrakis-β-diketonato complexes 5 and 6 have coordination number eight.

After consulting a lot of data, we found that this compound(1762-34-1)SDS of cas: 1762-34-1 can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem