Recently I am researching about ALCOHOLS, Saw an article supported by the Department of Science and Technology-Science and Engineering Research Board (DST-SERB), New Delhi [SRG/2019/002004]; Council of Scientific and Industrial Research (CSIR) New DelhiCouncil of Scientific & Industrial Research (CSIR) – India. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Sarki, N; Goyal, V; Tyagi, NK; Puttaswamy; Narani, A; Ray, A; Natte, K. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone. Product Details of 100-19-6
Methanol is a potential hydrogen source and C-1 synthon, which finds interesting applications in both chemical synthesis and energy technologies. The effective utilization of this simple alcohol in organic synthesis is of central importance and attracts scientific interest. Herein, we report a clean and cost-competitive method with the use of methanol as both C-1 synthon and H-2 source for selective N-methylation of amines by employing relatively cheap RuCl3.xH(2)O as a ligand-free catalyst. This readily available catalyst tolerates various amines comprising electron-deficient and electron-donating groups and allows them to transform into corresponding N-methylated products in moderate to excellent yields. In addition, few marketed pharmaceutical agents (e. g., venlafaxine and imipramine) were also successfully synthesized via late-stage functionalization from readily available feedstock chemicals, highlighting synthetic value of this advanced N-methylation reaction. Using this platform, we also attempted tandem reactions with selected nitroarenes to convert them into corresponding N-methylated amines using MeOH under H-2-free conditions including transfer hydrogenation of nitroarenes-to-anilines and prepared drug molecules (e. g., benzocaine and butamben) as well as key pharmaceutical intermediates. We further enable one-shot selective and green syntheses of 1-methylbenzimidazole using ortho-phenylenediamine (OPDA) and methanol as coupling partners.
Product Details of 100-19-6. Welcome to talk about 100-19-6, If you have any questions, you can contact Sarki, N; Goyal, V; Tyagi, NK; Puttaswamy; Narani, A; Ray, A; Natte, K or send Email.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem