In 2021.0 J HETEROCYCLIC CHEM published article about ANTIMITOTIC NATURAL-PRODUCTS; BIOLOGICAL EVALUATION; COLCHICINE SITE; ANALOGS; TUBULIN; BINDING; CYTOTOXICITY; INHIBITION; FLAVONOIDS; MECHANISM in [Rathnakar, Bethi; Kumar, Gajula S.; Mahammad, Saleem P.; Nimma, Rameshwar; Satyanarayana, Mavurapu] Telangana Univ, Dept Pharmaceut Chem, Nizamabad, India; [Gattu, Sridhar] CSIR IICT, Organ & Biomol Div, Hyderabad, India; [Kalyani, Sambaru] Mahatma Gandhi Univ, Dept Chem & Pharmaceut Sci, Nalgonda, India in 2021.0, Cited 55.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. SDS of cas: 100-19-6
A series of combretastatin A-4 based chalcones (14a-l) were designed, synthesized and these compounds examined for inhibitory effects on the proliferation of human lung (A549), breast (MCF-7), melanoma (A375), and colon (HT-29) carcinoma cells. Compounds 14b, 14c, 14e, 14h, and 14i (tri/dimethoxy, methyl, and mono/dinitro derivatives) have exhibited the most potent antiproliferative activity with IC50 < 2 mu M and the hexa methoxy derivative 14b, the most promising one, which displayed the potent inhibitory activities in MCF-7 (IC50: 10 nM), A375 (IC50: 12 nM), and A549 (IC50: 65 nM) cell lines, and is 18 times more potent than the CA-4. Compound 14b represents a new scaffold and the results provide insights into further development of anticancer agents. Bye, fridends, I hope you can learn more about C8H7NO3, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 100-19-6
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem