I found the field of Science & Technology – Other Topics very interesting. Saw the article Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study published in 2019.0. Quality Control of 1-(4-Nitrophenyl)ethanone, Reprint Addresses Taha, M (corresponding author), Imam Abdulrahman Bin Faisal Univ, Inst Res & Med Consultat, Dept Clin Pharm, POB 1982, Dammam 31441, Saudi Arabia.; Zakaria, ZA (corresponding author), Univ Putra Malaysia, Fac Med & Hlth Sci, Dept Biomed Sci, Serdang 43400, Selangor, Malaysia.; Zakaria, ZA (corresponding author), Univ Putra Malaysia, Halal Inst Res Inst, Serdang 43400, Selangor, Malaysia.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threats. In connection with this, we have synthesized twenty derivatives of isoquinoline bearing oxadiazole (1-20), characterized through different spectroscopic techniques such as HREI-MS, H-1-NMR and C-13-NMR and evaluated for thymidine phosphorylase inhibition. All analogues showed outstanding inhibitory potential ranging in between 1.10 +/- 0.05 to 54.60 +/- 1.50 mu M. 7-Deazaxanthine (IC50 = 38.68 +/- 1.12 mu M) was used as a positive control. Through limited structure activity relationships study, it has been observed that the difference in inhibitory activities of screened analogs are mainly affected by different substitutions on phenyl ring. The effective binding interactions of the most active analogs were confirmed through docking study.
Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zaman, K; Rahim, F; Taha, M; Wadood, A; Shah, SAA; Ahmed, QU; Zakaria, ZA or concate me.
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Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem