Meng, TT; Han, J; Zhang, PF; Hu, J; Fu, JJ; Yin, J in [Meng, Tingting; Zhang, Pengfei; Hu, Jing; Fu, Junjie; Yin, Jian] Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China; [Meng, Tingting; Fu, Junjie] Nanjing Med Univ, Sch Pharm, Nanjing 211166, Jiangsu, Peoples R China; [Han, Jing] Jiangsu Normal Univ, Sch Chem & Mat Sci, Jiangsu Key Lab Green Synthet Chem Funct Mat, Xuzhou 221116, Jiangsu, Peoples R China published Introduction of the alpha-ketoamide structure: en route to develop hydrogen peroxide responsive prodrugs in 2019.0, Cited 44.0. Quality Control of 1-(4-Nitrophenyl)ethanone. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6.
Leveraging the elevated levels of hydrogen peroxide (H2O2) in cancer, inflammatory diseases and cardiovascular disorders, H2O2-activated promoieties have been widely used in drugs and biomaterials design. However, the overwhelming majority of the promoieties only share the common structure of a H2O2-responsive arylboronic acid/ester moiety with low diversity. We report here an unprecedented strategy to construct novel H2O2-responsive prodrugs based on an alpha-ketoamide structure. As a proof of concept, we designed and synthesized a panel of alpha-ketoamide based nitrogen mustard prodrugs, among which KAM-2 showed potent growth inhibitory activity and high selectivity toward cancer cells. The H2O2-trigged decomposition of KAM-2 was validated, and the DNA damaging and apoptosis promoting activity attributed to the released nitrogen mustard were demonstrated. Our work unveils alpha-ketoamide as a new scaffold for prodrug design and may quickly inspire future developments.
Quality Control of 1-(4-Nitrophenyl)ethanone. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Meng, TT; Han, J; Zhang, PF; Hu, J; Fu, JJ; Yin, J or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem