Recommanded Product: 100-19-6. Authors Srilaxmi, D; Sreenivasulu, R; Mak, KK; Pichika, MR; Jadav, SS; Ahsan, MJ; Rao, MVB in ELSEVIER published article about in [Srilaxmi, Dandamudi; Rao, Mandava Venkata Basaveswara] Krishna Univ, Dept Chem, Machilipatnam 521001, Andhra Pradesh, India; [Sreenivasulu, Reddymasu] Jawaharlal Nehru Technol Univ, Univ Coll Engn Autonomous, Dept Chem, Kakinada 533003, Andhra Pradesh, India; [Mak, Kit-Kay; Pichika, Mallikarjuna Rao] Int Med Univ, Sch Pharm, Pharmaceut Chem Dept, 126,Jalan Jalil Perkasa 19 Bukit Jalil, Kuala Lumpur 57000, Malaysia; [Jadav, Surender Singh] Vishnu Inst Pharmaceut Educ & Res VIPER, Medak 502313, Telangana, India; [Ahsan, Mohamed Jawed] Maharishi Arvind Coll Pharm, Dept Pharmaceut Chem, Jaipur 302039, Rajasthan, India in 2021.0, Cited 69.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6
A series of novel chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) were designed, synthesized and their structures were confirmed by H-1 NMR, C-13 NMR and mass spectral data. Further, all derivatives were tested for their anticancer activities against five human cancer cell lines such as MCF-7 (breast cancer), A-549 (lung cancer), Colo-205 (colon cancer), A2780 (ovarian cancer) and DU-145 (prostate cancer) by employing MIT assay. The clinically used drug etoposide was used as standard reference and the anticancer activity was expressed as the IC50 in mu M. Among the ten compounds examined compounds, 10b, 10c, 10d, 10h, and 10i possessed more promising anticancer activity. A molecular docking study implying ATR kinase was carried out to observe the binding mode of chalcone derivatives pyrido[4,3-b]pyrazin-5(6H)-one (10a-j) on the active site of ATR kinase. The most promising compound, 10h showed pi – pi stacking interaction of trimethoxy phenyl and pyridone moiety with the residue Trp850, while the carbonyl (alpha,beta-unsaturated carbonyl) and methoxy functions showed H-bond interaction with the residue Ser773 and Thr856 respectively. (C) 2020 Elsevier B.V. All rights reserved.
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Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem