As the paragraph descriping shows that 4442-53-9 is playing an increasingly important role.
4442-53-9,4442-53-9, 2,3-Dihydrobenzo[b][1,4]dioxine-5-carboxylic acid is a benzodioxans compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
A.5.1 Synthesis of (IS^S.SRJ^-facylamino-methylJ-S-aza-bicycloIS.S.O]- octane-3-carboxylic acid tert. -butyl ester derivatives (general procedure)To a solution of the respective carboxylic acid R3-COOH (1 eq) in DMF (0.2 mmol/ 0.5 mL) are added successively DIPEA (5 eq) and TBTU (1 eq). The reaction mixture is stirred for 15 min. at RT and then is added a solution of (1S,2S,5R)-1- aminomethyl-3-aza-bicyclo[3.3.0]-octane-3-carboxylic acid te/t.-butyl ester derivative (1 eq) in DMF (0.5 ml_). The stirring at RT is continued for 16 h, the reaction mixture is poured into water and diluted with EA. The org. phase is washed with sat. NaHCOs solution and water. After drying over anh. MgSO4 and removal of solvents in vacuo the desired compounds are obtained which are used without further purification.(1S,2S,5R)-2-{[(3,4-Dihydro-benzo[1 ,4]dioxine-5-carbonyl)-amino]-methyl}-3- aza-bicyclo[3.3.0]octane-3-carboxylic acid tert. -butyl esterprepared by reaction of (I S^S.SR^I-aminomethyl-S-aza-bicyclobeta.S.OJ-octane-S- carboxylic acid te/t-butyl ester with commercially available 2,3-dihydro- benzo[1 ,4]dioxine-5-carboxylic acid.LC-MS: tR = 1.00 min; [M+H]+ = 403.
As the paragraph descriping shows that 4442-53-9 is playing an increasingly important role.
Reference£º
Patent; ACTELION PHARMACEUTICALS LTD; WO2009/4584; (2009); A1;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem