2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid, cas is 3663-80-7, it is a common heterocyclic compound, the benzodioxans compound, its synthesis route is as follows.
3663-80-7, The compound c ‘, HATU (2.0 equiv) was weighed into a reaction tube, evacuated, protected with argon, and dissolved in methylene chloride. DIPEA (3.0 equiv) was added dropwise at -15 ¡ã C and N-Boc-piperazine 1.5 equiv) was dissolved in methylene chloride, slowly added dropwise at -15 ¡ã C, and stirred overnight (12 h). (PE: EA = 2: 1) (successively eluted with PE: EA = 3: 1) to give a white solid, which is the compound d ‘ , Yield 97percent, optical purity 94percent ee (Chiralpak AD-H, 20percent isopropanol / hexane, 1.0 ml / min, tR (minor) = 6.2 min, tR (major) = 7.6 min).
With the rapid development of chemical substances, we look forward to future research findings about 2,3-Dihydrobenzo[b][1,4]dioxine-2-carboxylic acid
Reference£º
Patent; Guangzhou Institute Of Biomedicine And Health Chinese Academy Of Sciences; Cai, Qian; Huang, Yusha; (17 pag.)CN105985328; (2016); A;,
Benzodioxan
1,4-Benzodioxane | C8H8O2 – PubChem