Heterocyclic compounds can be divided into two categories: alicyclic heterocycles and aromatic heterocycles. Compounds whose heterocycles in the molecular skeleton cannot reflect aromaticity are called alicyclic heterocyclic compounds. Compound: 1762-34-1, is researched, Molecular C12H12N2, about A binuclear iron(III) complex of 5,5′-dimethyl-2,2′-bipyridine as cytotoxic agent, the main research direction is binuclear iron complex dimethyl bipyridine cytotoxic agent; 5,5′-dimethyl-2,2′-bipyridine; Binuclear iron(III) complex; Cytotoxicity; Fish salmon DNA.Synthetic Route of C12H12N2.
The binuclear iron(III) complex (1), namely, {[Fe(5,5′-dmbpy)2(OH2)]2(O)}(NO3)4 with a distorted octahedral coordination, formed by four nitrogen and two oxygen atoms, was previously reported by our team. In this study the DNA-binding and cytotoxicity evaluation for target complex were studied. The results indicated strong cytotoxicity activity against A549 cells comparable to cisplatin values. The binding interaction between complex 1 and FS-DNA was investigated by UV-Vis, fluorescence spectroscopy, and gel electrophoresis at physiol. pH (7.2). The DNA binding investigation has shown groove binding interactions with complex 1, therefore the hydrogen binding plays an important role in the interaction of DNA with complex 1. The calculated thermodn. parameters (ΔH°, ΔS° and ΔG°) show that hydrogen bonding and Vander-Waals forces have an important function in Fe(III) complex-DNA interaction. Moreover, DNA cleavage was studied using agarose gel electrophoresis. Viscosity measurements illustrated that relative viscosity of DNA was unchanged with the adding concentrations of Fe(III) complex. Mol. docking simulation results confirmed the spectroscopic and viscosity titration outcomes.
If you want to learn more about this compound(5,5′-Dimethyl-2,2′-bipyridine)Synthetic Route of C12H12N2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(1762-34-1).