So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Rashidipour, Arezoo; Alizadeh, Robabeh; Sadeghi Mohammadi, Sanam; Tohidlou, Mohammad; Amani, Vahid; Seyfi, Sara researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).Name: 5,5′-Dimethyl-2,2′-bipyridine.They published the article 《Synthesis, crystal structures and biological activity of palladium(II) complexes with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol and substituted 2,2′-bipyridines》 about this compound( cas:1762-34-1 ) in Journal of Coordination Chemistry. Keywords: palladium tetrazolethiol dimethylbipyridine complex preparation luminescence anticancer DNA binding; crystal structure palladium tetrazolethiol dimethylbipyridine complex. We’ll tell you more about this compound (cas:1762-34-1).
Reaction of PdCl2 with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol (Hmtzt) in the presence of 5,5′-dimethyl-2,2′-bipyridine (5,5′-dmbipy) and 4,4′-dimethyl-2,2′-bipyridine ligands (4,4′-dmbipy) afforded two new Pd(II) complexes, [Pd(5,5′-dmbipy)(mtzt)2] (1) and [Pd(4,4′-dmbipy)(mtzt)2] (2), resp. The two complexes were thoroughly characterized by elemental anal., UV-vis, 1H NMR, IR, luminescence spectroscopy as well as single-crystal X-ray diffraction. Single-crystal X-ray diffraction revealed that central Pd(II) ions in and are tetra-coordinated, presenting distorted and slightly distorted square planar geometry around Pd atom for and , resp. The luminescence properties of free ligands and complexes 1 and 2, in solution, were investigated. The biol. evaluation of the Pd(II) complexes showed that they exhibited anticancer activities in a dose-dependent manner against human breast cancer cell lines. Also, their in vitro interaction with DNA were analyzed through spectrophotometric, spectrofluorometric, and gel-electrophoresis which shows the intercalation mode of binding. In conclusion, these palladium complexes represent novel anticancer drug mols. for further study.
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