New discoveries in chemical research and development in 2021. Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage. In a patent，Which mentioned a new discovery about name: 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime, name: 2,3-Dihydrobenzo[b][1,4]dioxine-6-carbaldehyde oxime
In this research several series of novel dioxygenated ring fused 4-anilinoquinazolines (10a-d) and 4-anilinoquinazoline-substituted triazole hybrid compounds (11?14) have been designed and synthesized. Their biological significance was highlighted by evaluating in vitro for anticancer activities, wherein several compounds displayed excellent activity specifically against three human cancer cell lines (KB, epidermoid carcinoma; HepG2, hepatoma carcinoma; SK-Lu-1, non-small lung cancer). Especially, compound 13a exhibited up to 100-fold higher cytotoxicity in comparison with erlotinib. Docking the most cytotoxic compounds (11d, 13a, 13b, and 14c) into the ATP binding site of different EGFR tyrosine kinase domains was perfomed to predict the analogous binding mode of these compounds to the EGFR targets.
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