214894-89-0, Irreversible inhibitors are therefore the equivalent of poisons in heterogeneous catalysis.Enzyme inhibitors cause a decrease rate of an enzyme-catalyzed reaction to a specific portion of an enzyme and thus slowing a reaction . In an article, 214894-89-0, molcular formula is C9H9BrO2, introducing its new discovery.
We report the preliminary results of the synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a number of phenyl alkyl imidazole-based compounds as inhibitors of the two components of 17alpha-hydroxylase/17,20-lyase (P45017alpha), that is, 17alpha-hydroxylase (17alpha-OHase) and 17,20-lyase (lyase). The results show that N-3-(4-bromophenyl) propyl imidazole (12) (IC50 = 2.95 muM against 17alpha-OHase and IC50 = 0.33 muM against lyase) is the most potent compound within the current study, in comparison to ketoconazole (KTZ) (IC50 = 3.76 muM against 17alpha-OHase and IC50 = 1.66 muM against lyase). Modelling of these compounds suggests that the length of the alkyl chain enhances the interaction between the inhibitor and the area of the active site corresponding to the C(3) area of the steroid backbone, thereby increasing potency.
Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.214894-89-0. In my other articles, you can also check out more blogs about 214894-89-0