Yamada, Shuya; Kaneda, Takeshi; Steib, Philip; Murakami, Kei; Itami, Kenichiro published the article 《Dehydrogenative Synthesis of 2,2′-Bipyridyls through Regioselective Pyridine Dimerization》. Keywords: pyridine palladium catalyst regioselective dimerization dehydrogenative silver pivalic acid; bipyridyl preparation; 2,2′-bipyridyls; C−H arylation; dehydrogenative coupling; palladium; pyridines.They researched the compound: 5,5′-Dimethyl-2,2′-bipyridine( cas:1762-34-1 ).Recommanded Product: 5,5′-Dimethyl-2,2′-bipyridine. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:1762-34-1) here.
2,2′-Bipyridyls have been utilized as indispensable ligands in metal-catalyzed reactions. The most streamlined approach for the synthesis of 2,2′-bipyridyls is the dehydrogenative dimerization of unfunctionalized pyridine. Herein, we report on the palladium-catalyzed dehydrogenative synthesis of 2,2′-bipyridyl derivatives The Pd catalysis effectively works with an AgI salt as the oxidant in the presence of pivalic acid. A variety of pyridines regioselectively react at the C2-positions. This dimerization method is applicable for challenging substrates such as sterically hindered 3-substituted pyridines, where the pyridines regioselectively react at the C2-position. This reaction enables the concise synthesis of twisted 3,3′-disubstituted-2,2′-bipyridyls as an underdeveloped class of ligands.
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