An article Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors WOS:000463339500006 published article about BIOLOGICAL EVALUATION; ACID-DERIVATIVES; HYPERURICEMIA in [Zhang, Lichao; Wang, Sibo; Bao, Kai] Shenyang Pharmaceut Univ, Wuya Coll Innovat, Shenyang 110016, Liaoning, Peoples R China; [Yang, Mingzheng; Guan, Qi] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Liaoning, Peoples R China; [Shi, Ailong; Wang, He; Zhang, Weige] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019.0, Cited 28.0. The Name is 1-(4-Nitrophenyl)ethanone. Through research, I have a further understanding and discovery of 100-19-6. HPLC of Formula: C8H7NO3
In view of expanding the structure activity relationship of xanthine oxidase inhibitors, a series of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide/carboxylic acid derivatives were designed by molecular docking and synthesized. All the target compounds were evaluated for their in vitro XO inhibition by using febuxostat and allopurinol as the standard controls. Most of the hydrazide derivatives exhibited potency levels in the micromolar range. From the view of docking study, hydrazide derivatives bind to the active site of XO through a novel interaction mode, which is different from that of febuxostat bearing a carboxyl group. The most promising compound 8b was further subjected to kinetic analysis to deduce their modes of inhibition.
Welcome to talk about 100-19-6, If you have any questions, you can contact Zhang, LC; Wang, SB; Yang, MZ; Shi, AL; Wang, H; Guan, Q; Bao, K; Zhang, WG or send Email.. HPLC of Formula: C8H7NO3
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem