Authors Lippa, RA; Battersby, DJ; Murphy, JA; Barrett, TN in AMER CHEMICAL SOC published article about in [Lippa, Rhys A.; Murphy, John A.] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland; [Battersby, David J.; Barrett, Tim N.] GlaxoSmithKline, Med Sci & Technol, Stevenage SG1 2NY, Herts, England in 2021, Cited 51. COA of Formula: C14H11N. The Name is 2,2-Diphenylacetonitrile. Through research, I have a further understanding and discovery of 86-29-3
Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp(3))-C(sp(3)) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.
COA of Formula: C14H11N. About 2,2-Diphenylacetonitrile, If you have any questions, you can contact Lippa, RA; Battersby, DJ; Murphy, JA; Barrett, TN or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem