Reference of 70918-54-6, New Advances in Chemical Research in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 70918-54-6, Name is (S)-1,4-Benzodioxane-2-carboxylic acid. In a Article, once mentioned of 70918-54-6.
The synthesis of some cyclic and open analogues of 2-(2,6-dimethoxyphenoxyethylaminomethyl)-1,4-benzodioxane (1, WB 4101) is described. The blocking activity of this compound and its analogues (1-5) was determined on the pre- and postsynaptic alpha-adrenoceptors of isolated rat vas deferens to investigate the structural requirements for conpetitive alpha-adrenoceptor occupancy by antagonists of the benzodioxane class. The activities of 1-5 at the presynaptic alpha-adrenoceptor were not significantly different whereas there were differences among the compounds of at least two orders of magnitude at the postsynaptic alpha-adrenoceptor. This clearly indicates that the structural requirements at the presynaptic receptor level are less restrictive than those required by the postsynaptic alpha-adrenoceptor. The symmetric analogues 3 and 4 were significantly weaker postsynaptic alpha-antagonists compared to 1. On the other hand, 2 and 5 displayed a very high postsynaptic activity, almost comparable to that of 1. These findings might suggest that the antagonists of the benzodioxane class do not bind at two identical aromatic sites symmetrically arranged around the anionic site of the alpha-adrenoceptor. Indeed, they might indicate that the benzodioxane binding site(s) incorporates two areas with very similar but not identical structural requirements. Furthermore, the very high activity of 5 may suggest that the benzodioxane nucleus is not essential to activity.
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