Application of 3663-79-4, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.3663-79-4, Name is Methyl 1,4-Benzodioxane-2-carboxylate, molecular formula is C10H10O4. In a Article£¬once mentioned of 3663-79-4
Structure based discovery of novel hexokinase 2 inhibitors
Hexokinase 2 (HK2) is over-expressed in most of human cancers and has been proved to be a promising target for cancer therapy. In this study, based on the structure of HK2, we screened over 6 millions of compounds to obtain the lead. A total of 26 (E)-N?-(2,3,4-trihydroxybenzylidene) arylhydrazide derivatives were then designed, synthesized, and evaluated for their HK2 enzyme activity and IC50 values against two cancer cell lines. Most of the 26 target compounds showed excellently in vitro activity. Among them, compound 3j showed the strongest inhibitory effects on HK2 enzyme activity with an IC50 of 0.53 ¡À 0.13 muM and exhibited the most potent growth inhibition against SW480 cells with an IC50 of 7.13 ¡À 1.12 muM, which deserves further studies.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 3663-79-4
Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem