In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2879-20-1, name is 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone. In an article£¬Which mentioned a new discovery about 2879-20-1
A novel method for preparing Eligulstat through chiral resolution
Eliglustat is a ceramide glucosyltransferase inhibitor work as first line oral therapy for adults with Gaucher disease type 1 (a rare disease) at present. Although the eliglustat in enantiomerically pure forms is obtained by asymmetric syntheses, the reported methods suffer from many limits when it comes to industrial applications. Therefore, the preparation of a racemic mixture followed by resolution can still be a viable and straightforward alternative, especially when it could be adapted to large scale. Herein, we developed an effective and practical synthetic route to prepare stereoisomers mixture of eliglustat, and a novel chiral resolution method to prepare eliglustat. Using 1,1?-Binaphthyl-2,2?-diyl -hydrogenphosphate (BNDHP) as resolution reagent, optical pure eliglustat (e.e. >99%, 13.97% total yield) could be obtained after recrystallization.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 2879-20-1, help many people in the next few years.Recommanded Product: 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)ethanone
Reference£º
Benzodioxan,
1,4-Benzodioxane | C8H8O2 – PubChem