COA of Formula: C8H7NO3. I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis and Bioactivity of Thiosemicarbazones Containing Adamantane Skeletons published in 2020.0, Reprint Addresses Vu, BD (corresponding author), Vietnam Mil Med Univ, Drug R&D Ctr, 160,Phung Hung St,Phuc La Ward, Hanoi 100000, Vietnam.; Phan, DC (corresponding author), Hanoi Univ Sci & Technol, 1,Dai Co Viet St,Bach Khoa Ward, Hanoi 100000, Vietnam.. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone.
Reaction of 4-(1-adamantyl)-3-thiosemicarbazide (1) with numerous substituted acetophenones and benzaldehydes yielded the corresponding thiosemicarbazones containing adamantane skeletons. The synthesized compounds were evaluated for their in vitro activities against some Gram-positive and Gram-negative bacteria, and the fungus Candida albicans, and cytotoxicity against four cancer cell lines (Hep3B, HeLa, A549, and MCF-7). All of them showed good antifungal activity against Candida albicans. Compounds 2c, 2d, 2g, 2j and 3a, 3e, 3g displayed significant inhibitory activity against Enterococcus faecalis. Compounds 2a, 2e, 2h, 2k and 3j had moderate inhibitory potency against Staphylococcus aureus. Compounds 2a, 2e and 2g found so good inhibitory effect on Bacillus cereus. Compounds 2d and 2h, which contain (ortho) hydroxyl groups on the phenyl ring, were shown to be good candidates as potential agents for killing the tested cancer cell lines, i.e., Hep3B, A549, and MCF-7. Compounds 2a-c, 2f, 2g, 2j, 2k, 3g, and 3i were moderate inhibitors against MCF-7.
COA of Formula: C8H7NO3. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Pham, VH; Phan, TPD; Phan, DC; Vu, BD or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem