Category: benzodioxans. Recently I am researching about BIOLOGICAL EVALUATION; IN-VITRO; DERIVATIVES; ANTICANCER; MECHANISM; POISONS; SERIES, Saw an article supported by the National Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81502911]; Municipal Program for Science and Technology of Guangzhou [202002030212]. Published in MDPI in BASEL ,Authors: Zhou, W; Zhang, WJ; Peng, Y; Jiang, ZH; Zhang, LY; Du, ZY. The CAS is 100-19-6. Through research, I have a further understanding and discovery of 1-(4-Nitrophenyl)ethanone
Chemical diversification of type II topoisomerase (Topo II) inhibitors remains indispensable to extend their anti-tumor therapeutic values which are limited by their side effects. Herein, we designed and synthesized a novel series of benzimidazole-chalcone hybrids (BCHs). These BCHs showed good inhibitory effect in the Topo II mediated DNA relaxation assay and anti-proliferative effect in 4 tumor cell lines.4dand4nwere the most potent, with IC(50)values less than 5 mu M, superior to etoposide. Mechanistic studies indicated that the BCHs functioned as non-intercalative Topo II catalytic inhibitors. Moreover,4dand4ndemonstrated versatile properties against tumors, including inhibition on the colony formation and cell migration, and promotion of apoptosis of A549 cells. The structure-activity relationship and molecular docking analysis suggested possible contribution of the chalcone motif to the Topo II inhibitory and anti-proliferative potency. These results indicated that4dand4ncould be promising lead compounds for further anti-tumor drug research.
Category: benzodioxans. About 1-(4-Nitrophenyl)ethanone, If you have any questions, you can contact Zhou, W; Zhang, WJ; Peng, Y; Jiang, ZH; Zhang, LY; Du, ZY or concate me.
Reference:
Benzodioxan,
,1,4-Benzodioxane | C8H8O2 – PubChem